Results 191 to 200 of about 6,341,201 (297)

Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome. [PDF]

Nat Commun
Wang X, Li Y, Lin Z, Pla I, Gajjela R, Mattamana BB, Joshi M, Liu Y, Wang H, Zun AB, Wang H, Wai CM, Agrawal V, Dunton CL, Duan C, Jiang B, Backman V, He TC, Reid RR, Luo Y, Ameer GA.   +20 more
europepmc   +1 more source

Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus. [PDF]

Cells, 2021
Kachaev ZM, Ivashchenko SD, Kozlov EN, Lebedeva LA, Shidlovskii YV.   +4 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Interplay of chromatin organization and mechanics of the cell nucleus. [PDF]

Biophys J
De Corato M, Gomez-Benito MJ.
europepmc   +1 more source

The effects of measurement parameters on the cancerous cell nucleus characterisation by atomic force microscopy in vitro. [PDF]

J Microsc, 2022
Zhu J, Tian Y, Yan J, Hu J, Wang Z, Liu X.   +5 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Heterogeneous flexibility can contribute to chromatin segregation in the cell nucleus. [PDF]

Phys Rev E
Girard M, de la Cruz MO, Marko JF, Erbaş A.   +3 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

FrozONE: quick cell nucleus enrichment for comprehensive proteomics analysis of frozen tissues. [PDF]

Life Sci Alliance
Huschet LA, Kliem FP, Wienand P, Wunderlich CM, Ribeiro A, Bustos-Martínez I, Barco Á, Wunderlich FT, Lech M, Robles MS.   +9 more
europepmc   +1 more source

Cell nucleus as a microrheological probe to study the rheology of the cytoskeleton. [PDF]

Biophys J, 2021
Moradi M, Nazockdast E.
europepmc   +1 more source