Results 181 to 190 of about 827,170 (307)

Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer's Disease. [PDF]

Cells, 2022
Cosacak MI, Bhattarai P, De Jager PL, Menon V, Tosto G, Kizil C.   +5 more
europepmc   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Stepwise virus assembly in the cell nucleus revealed by spatiotemporal click chemistry of DNA replication. [PDF]

Sci Adv
Gomez-Gonzalez A, Burkhardt P, Bauer M, Suomalainen M, Mateos JM, Loehr MO, Luedtke NW, Greber UF.   +7 more
europepmc   +1 more source

Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus. [PDF]

Int J Mol Sci, 2022
Fernandes C, Palma E, Silva F, Belchior A, Pinto CIG, Guerreiro JF, Botelho HM, Mendes F, Raposinho P, Paulo A.   +9 more
europepmc   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Sex-specific proximal tubular cell differentiation pathways identified by single-nucleus RNA sequencing [PDF]

Yueh-An Lu, Tanya Smith, Sumukh Deshpande, Chia‐Te Liao, Bnar Talabani, I. V. Grigorieva, Anna Mason, Robert Andrews, Timothy Bowen, Philip R. Taylor, Donald Fraser   +10 more
openalex   +1 more source

Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration [PDF]

, 2019
Zheng Li, Xin Chen, Yuming Zhong, Shugang Li, Matthew T.V. Chan, William Ka Kei Wu   +5 more
openalex   +1 more source

The effect of doxycycline and collagenase A on the differentiation of mesenchymal stem cells towards a nucleus pulposus phenotype

, 2021
Olena Bojchuk
openalex   +2 more sources

FERM domain-containing proteins are active components of the cell nucleus. [PDF]

Life Sci Alliance
Borkúti P, Kristó I, Szabó A, Kovács Z, Vilmos P.   +4 more
europepmc   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source