Results 181 to 190 of about 1,337,831 (333)

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Mechanical Frustration of Phase Separation in the Cell Nucleus by Chromatin. [PDF]

Phys Rev Lett, 2021
Zhang Y, Lee DSW, Meir Y, Brangwynne CP, Wingreen NS.   +4 more
europepmc   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

The effects of measurement parameters on the cancerous cell nucleus characterisation by atomic force microscopy in vitro. [PDF]

J Microsc, 2022
Zhu J, Tian Y, Yan J, Hu J, Wang Z, Liu X.   +5 more
europepmc   +1 more source

ON THE ROLE OF HISTONES IN REGULATING RIBONUCLEIC ACID SYNTHESIS IN THE CELL NUCLEUS

, 1963
V. G. Allfrey, Virginia C. Littau, A. E. Mirsky   +2 more
openalex   +1 more source

Virus-Specific Ribonucleic Acid in the Nucleus and Cytoplasm of Rat Embryo Cells Transformed by Adenovirus Type 2 [PDF]

, 1972
Koichiro Shimada, Kei Fujinaga, Seiji Hama, Kenji Sekikawa, Yôhei Itô   +4 more
openalex   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Localization and Functional Roles of Components of the Translation Apparatus in the Eukaryotic Cell Nucleus. [PDF]

Cells, 2021
Kachaev ZM, Ivashchenko SD, Kozlov EN, Lebedeva LA, Shidlovskii YV.   +4 more
europepmc   +1 more source

RNA SYNTHESIS IN CELLS INFECTED WITH HERPES SIMPLEX VIRUS, II. EVIDENCE THAT A CLASS OF VIRAL mRNA IS DERIVED FROM A HIGH MOLECULAR WEIGHT PRECURSOR SYNTHESIZED IN THE NUCLEUS

, 1969
Edward K. Wagner, Bernard Roizman
openalex   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source