Results 31 to 40 of about 827,170 (307)

Actomyosin contractility rotates the cell nucleus [PDF]

Scientific Reports, 2013
The nucleus of the eukaryotic cell functions amidst active cytoskeletal filaments, but its response to the stresses carried by these filaments is largely unexplored. We report here the results of studies of the translational and rotational dynamics of the nuclei of single fibroblast cells, with the effects of cell migration suppressed by plating onto ...
Kumar, Abhishek, Maitra, Ananyo, Sumit, Madhuresh, Ramaswamy, Sriram, Shivashankar, G   +4 more
openaire   +5 more sources

Cell nucleus and English letters [PDF]

Journal of Thoracic Disease, 2017
Cell nucleus and English letters seem to be two totally unrelated concepts. How could they be connected?
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Alteration of actin cytoskeletal organisation in fetal akinesia deformation sequence

Scientific Reports
Fetal akinesia deformation sequence (FADS) represents the severest form of congenital myasthenic syndrome (CMS), a diverse group of inherited disorders characterised by impaired neuromuscular transmission.
Ramona Jühlen, Lukas Grauer, Valérie Martinelli, Chantal Rencurel, Birthe Fahrenkrog   +4 more
doaj   +1 more source

Follicular thyroid lesions: is there a discriminatory potential in the computerized nuclear analysis?

Endocrine Connections, 2018
Background: Computerized image analysis seems to represent a promising diagnostic possibility for thyroid tumors. Our aim was to evaluate the discriminatory diagnostic efficiency of computerized image analysis of cell nuclei from histological materials ...
Flávia O Valentim, Bárbara P Coelho, Hélio A Miot, Caroline Y Hayashi, Danilo T A Jaune, Cristiano C Oliveira, Mariângela E A Marques, José Vicente Tagliarini, Emanuel C Castilho, Paula Soares, Gláucia M F S Mazeto   +10 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Dual-color dSTORM imaging and ThunderSTORM image reconstruction and analysis to study the spatial organization of the nuclear phosphatidylinositol phosphates

MethodsX, 2021
Single molecule localization microscopy (SMLM) provided an unprecedented insight into the sub-nuclear organization of proteins and nucleic acids but apart from the nuclear envelope the role of the nuclear lipids in the functional organization of the cell
Peter Hoboth, Ondřej Šebesta, Martin Sztacho, Enrique Castano, Pavel Hozák   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Systems biology in the cell nucleus [PDF]

Journal of Cell Science, 2005
The mammalian nucleus is arguably the most complex cellular organelle. It houses the vast majority of an organism's genetic material and is the site of all major genome regulatory processes. Reductionist approaches have been spectacularly successful at dissecting at the molecular level many of the key processes that occur within the nucleus ...
Stanislaw, Gorski, Tom, Misteli
openaire   +2 more sources