Results 41 to 50 of about 1,337,831 (333)
A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus [PDF]
, 2008 Cell-cell contacts play a vital role in intracellular signaling, although the molecular mechanisms of these signaling pathways are not fully understood. E-cadherin, an important mediator of cell-cell adhesions, has been shown to be cleaved by γ-secretase.
Ariga, H +7 more
core +2 more sources
Numerical simulations of elastic capsules with nucleus in shear flow
, 2017 The shear-induced deformation of a capsule with a stiff nucleus, a model of eukaryotic cells, is studied numerically. The membrane of the cell and of its nucleus are modelled as a thin and impermeable elastic material obeying a Neo-Hookean constitutive ...
Banaei, Arash Alizad +3 more
core +1 more source
Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol [PDF]
, 2017 © 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ
B Calippe +42 more
core +4 more sources
Transport in and out of the cell nucleus [PDF]
Biochemical Society Transactions, 1998 A hallmark of eukaryotic cells is their separation into compartments. These compartments are surrounded by membranes that are impermeable to macromolecules. As most proteins are synthesised in the cytoplasm, specific transport systems have evolved to allow proteins to be imported from the cytoplasm into these compartments.
openaire +5 more sources
Evolutionary insights into premetazoan functions of the neuronal protein homer. [PDF]
, 2014 Reconstructing the evolution and ancestral functions of synaptic proteins promises to shed light on how neurons first evolved. The postsynaptic density (PSD) protein Homer scaffolds membrane receptors and regulates Ca(2+) signaling in diverse metazoan ...
Burkhardt, Pawel +5 more
core +1 more source
Modular Nanotransporters for Nuclear-Targeted Delivery of Auger Electron Emitters
Frontiers in Pharmacology, 2018 This review describes artificial modular nanotransporters (MNTs) delivering their cargos into target cells and then into the nuclei – the most vulnerable cell compartment for most anticancer agents and especially for radionuclides emitting short-range ...
Alexander S. Sobolev +1 more
doaj +1 more source
The Role of Nuclear Insulin and IGF1 Receptors in Metabolism and Cancer
Biomolecules, 2021 Insulin (InsR) and insulin-like growth factor-1 (IGF1R) receptors mediate the metabolic and growth-promoting actions of insulin and IGF1/IGF2, respectively.
Haim Werner, Rive Sarfstein, Zvi Laron
doaj +1 more source
The subthalamic nucleus : Part I: Development, cytology, topography and connections [PDF]
, 2008 This monograph on the subthalamic nucleus accentuates in Part I the gap between experimental animal and human information concerning subthalamic development, cytology, topography and connections. The light and electron microscopical cytology concerns the
Heida, Tjitske +3 more
core +3 more sources
Joint profiling of DNA methylation and chromatin architecture in single cells. [PDF]
, 2019 We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the ...
AD Schmitt +31 more
core +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source