Results 81 to 90 of about 827,170 (307)

Characterization of diverse populations of sinoatrial node cells and their proliferation potential at single nucleus resolution

, 2022
Jia-Hua Qu, Richard Telljohann, Rostislav Byshkov, Edward G. Lakatta   +3 more
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Nicotinamide Phosphoribosyltransferase Inhibitor APO866 Prevents IL-1β-Induced Human Nucleus Pulposus Cell Degeneration via Autophagy [PDF]

, 2018
Changgui Shi, Huiqiao Wu, Di Du, Hee‐Jeong Im, Ying Zhang, Bo Hu, Huajiang Chen, Xinwei Wang, Yang Liu, Peng Cao, Ye Tian, Xiaolong Shen, Rui Gao, André J. van Wijnen, Xiaojian Ye, Y. Edward Wen   +15 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Single-channel recording of inositol trisphosphate receptor in the isolated nucleus of a muscle cell line

Biological Research, 2006
Nuclear calcium appears to have an important role in the regulation of gene expression in many cells, but the mechanisms involved in controlling nuclear Ca2+ signaling are controversial and still poorly understood.
CARLOS KUSNIER, CÉSAR CÁRDENAS, JORGE HIDALGO, ENRIQUE JAIMOVICH   +3 more
doaj  

Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells [PDF]

, 2019
Marianna Guida, Alessandra Zanon, Luigi Montibeller, Alexandros Α. Lavdas, Judith Ladurner, Francesca Pischedda, Aleksandar Raković, Francisco S. Domingues, Giovanni Piccoli, Christine Klein, Peter P. Pramstaller, Andrew A. Hicks, Irene Pichler   +12 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Extraction and evaluation of cell nuclei images in label-free phase contrast microscopy enabled by machine learning using a data analysis platform Usiigaci

Nihon Kikai Gakkai ronbunshu
Recently, machine learning has been applied as a powerful tool for determining cell functions and states from cell shape features in microscopic images.
Kazuaki NAGAYAMA, Miku OHASHI, Hotaka DANGI, Koujin TAKEDA   +3 more
doaj   +1 more source

Correction to: Cartilage Endplate Stem Cells Inhibit Intervertebral Disc Degeneration by Releasing Exosomes to Nucleus Pulposus Cells to Activate Akt/Autophagy [PDF]

, 2023

openalex   +1 more source