Results 91 to 100 of about 1,388,881 (305)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The effect of nucleus size on the cell dose in targeted radionuclide therapy – A monte carlo study
Journal of Medical Signals and Sensors, 2020 Background: Nowadays, the use of radiopharmaceuticals in medicine is unavoidable. Depending on the distribution of the radiopharmaceutical in the cells, the nucleus absorbed dose changes by the variations in their geometry size.
Ebrahim Kouhkan +2 more
doaj +1 more source
Laser Microirradiation of Chinese Hamster Cells at Wavelength 365 nm [PDF]
, 1981 Cells of a V79 subline of the Chinese hamster were microirradiated at wavelength 365 nm in the presence of the psoralen derivative, trioxsalen. Microirradiation was accomplished by a pulsed argon laser microbeam either in anaphase or in interphase 3 hr ...
Berns, Michael W. +3 more
core
Nucleus downscaling in mouse embryos is regulated by cooperative developmental and geometric programs [PDF]
, 2016 Maintaining appropriate nucleus size is important for cell health, but the mechanisms by which this is achieved are poorly understood. Controlling nucleus size is a particular challenge in early development, where the nucleus must downscale in size with ...
FitzHarris, G, Tsichlaki, E
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The site of ribonucleic acid synthesis in the isolated nucleus [PDF]
, 1961 There is still controversy concerning the primary site of RNA synthesis in the cell.(1) When tissues are radioautographed after administration of radioactive inorganic phosphorus or radioactive RNA(2) precursors such as tritiated uridine or cytidine, it ...
Bonner, James, Rho, Joon H.
core
A framework for quantification and physical modeling of cell mixing applied to oscillator synchronization in vertebrate somitogenesis [PDF]
, 2017 In development and disease, cells move as they exchange signals. One example is found in vertebrate development, during which the timing of segment formation is set by a ‘segmentation clock’, in which oscillating gene expression is synchronized across a ...
Bhavna, Rajasekaran +3 more
core +4 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Cell Injection Millirobot Development and Evaluation in Microfluidic Chip
Micromachines, 2018 We propose an innovative design of millirobot, which can achieve donor cell suction, delivery, and injection in a mammalian oocyte on a microfluidic chip.
Lin Feng +6 more
doaj +1 more source