Results 41 to 50 of about 23,513,766 (356)

Cellularity of adipose depots in six strains of genetically obese mice

Journal of Lipid Research, 1972
Adipocyte cell size and number of three adipose depots, gonadal, subcutaneous, and retroperitoneal, were determined in several strains (aAy, aAiy, dbdb, obob, and NZO) of adult genetically obese mice, male and female, and in male gold thioglucose-treated
P.R. Johnson, Jules Hirsch
doaj   +1 more source

A single–cell type transcriptomics map of human tissues

Science Advances, 2021
Single-cell RNA analysis has been integrated with spatial protein profiling to create a single–cell type map of human tissues. Advances in molecular profiling have opened up the possibility to map the expression of genes in cells, tissues, and organs in ...
Max J. Karlsson, Cheng Zhang, Loren Méar, Wen Zhong, A. Digre, Borbala Katona, E. Sjöstedt, L. Butler, J. Odeberg, P. Dusart, F. Edfors, P. Oksvold, K. von Feilitzen, M. Zwahlen, M. Arif, O. Altay, Xiangyu Li, M. Ozcan, Adil Mardonoglu, Linn Fagerberg, J. Mulder, Yonglun Luo, F. Pontén, M. Uhlén, C. Lindskog   +24 more
semanticscholar   +1 more source

Quantification and correlation of amyloid-β plaque load, glial activation, GABAergic interneuron numbers, and cognitive decline in the young TgF344-AD rat model of Alzheimer’s disease

Frontiers in Aging Neuroscience
BackgroundAnimal models of Alzheimer’s disease (AD) are essential tools for investigating disease pathophysiology and conducting preclinical drug testing.
Anett Futácsi, Anett Futácsi, Anett Futácsi, Kitti Rusznák, Kitti Rusznák, Gergely Szarka, Gergely Szarka, Gergely Szarka, Béla Völgyi, Béla Völgyi, Ove Wiborg, Boldizsár Czéh, Boldizsár Czéh, Boldizsár Czéh   +13 more
doaj   +1 more source

Effects of transportation time after extraction on the magnetic cryopreservation of pulp cells of rat dental pulp

Journal of Dental Sciences, 2011
Background/purpose: The aim of this study was to examine the effects of the time period between tooth extraction and the freezing procedure on pulp cells in frozen intact teeth of rats.
Mao-Suan Huang, Wei-Jen Chang, Haw-Ming Huang, Yen-Chuang Lin, Yen-Hua Huang, Jen-Chang Yang, Sheng-Yang Lee   +6 more
doaj   +1 more source

Dimensionality reduction for visualizing single-cell data using UMAP

Nature Biotechnology, 2018
Advances in single-cell technologies have enabled high-resolution dissection of tissue composition. Several tools for dimensionality reduction are available to analyze the large number of parameters generated in single-cell studies. Recently, a nonlinear
E. Becht, Leland McInnes, John Healy, C. Dutertre, Immanuel Kwok, L. Ng, F. Ginhoux, E. Newell   +7 more
semanticscholar   +1 more source

Cellularity of adipose depots in the genetically obese Zucker rat

Journal of Lipid Research, 1971
Cell size and number of three adipose depots, epididymal, retroperitoneal, and subcutaneous, were determined during growth of the obese Zucker rat (“fatty”) and nonobese Zucker control.
P.R. JOHNSON, L.M. ZUCKER, J.A.F. CRUCE, JULES HIRSCH   +3 more
doaj   +1 more source

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

Frontiers in Pharmacology
IntroductionThe HepaRG cell line has become a widely used model for liver toxicity testing due to the expression of cytochrome P450 enzymes essential for phase I metabolism of endogenous and exogenous compounds. As variations in expression may pose human
Kristina Jochum, Veronika Städele, Philip Marx-Stoelting   +2 more
doaj   +1 more source

How Cell Number and Cellular Properties of Blood-Banked Red Blood Cells of Different Cell Ages Decline during Storage

PLoS ONE, 2014
Aims Numerous studies have suggested that transfusion of red blood cells (RBCs) stored over a long period of time may induce harmful effects due to storage-induced lesions.
Wei-Wei Tuo, Di Wang, Wen-Jing Liang, Yaoxiong Huang   +3 more
semanticscholar   +1 more source

Single-cell copy number variation detection [PDF]

Genome Biology, 2011
AbstractDetection of chromosomal aberrations from a single cell by array comparative genomic hybridization (single-cell array CGH), instead of from a population of cells, is an emerging technique. However, such detection is challenging because of the genome artifacts and the DNA amplification process inherent to the single cell approach.
Cheng, Jiqiu, Vanneste, Evelyne, Konings, Peter, Voet, Thierry, Vermeesch, Joris R, Moreau, Yves   +5 more
openaire   +2 more sources

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source