Results 271 to 280 of about 73,798 (303)

Classes of Cell-Penetrating Peptides

2015
During the three decades of cell-penetrating peptides era the superfamily of CPPs has rapidly expanded, and the quest for new sequences continues. CPPs have been well recognized by scientific community and they have been used for transduction of a wide variety of molecules and particles into cultured cells and in vivo.
Margus, Pooga, Ülo, Langel
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Transduction of peptides and proteins into live cells by cell penetrating peptides

Journal of Cellular Biochemistry, 2011
Internalization of peptides and proteins into live cells is an essential prerequisite for studies on intracellular signal pathways, for treatment of certain microbial diseases and for signal transduction therapy, especially for cancer treatment. Cell penetrating peptides (CPPs) facilitate the transport of cargo-proteins through the cell membrane into ...
Franziska, Mussbach, Martin, Franke, Ansgar, Zoch, Buerk, Schaefer, Siegmund, Reissmann   +4 more
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Studying the uptake of cell-penetrating peptides

Nature Protocols, 2006
More than a decade ago, it was discovered that cationic peptides could traverse the cellular plasma membrane without specific transporter proteins or membrane damage. Subsequently, it was found that these peptides, known as cell-penetrating peptides (CPPs), were also capable of delivering cargos into cells, hence the great potential of these vectors ...
Tina, Holm, Henrik, Johansson, Pontus, Lundberg, Margus, Pooga, Maria, Lindgren, Ulo, Langel   +5 more
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Cell Penetrating Peptides for Tumor Targeting

Current Pharmaceutical Biotechnology, 2011
Anticancer drug delivery has been hindered due to cell membrane permeability and the lack of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs and has therefore been considered to be an essential step for achieving therapeutic efficacy.
Young Suk, Choi, Jue Yeon, Lee, Jin Sook, Suh, Seung Jin, Lee, Victor C, Yang, Chong Pyoung, Chung, Yoon Jeong, Park   +6 more
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Therapeutic Potential of cell-penetrating Peptides

Therapeutic Delivery, 2013
The ability of cell-penetrating peptides to cross plasma membranes has been used for various applications, including the delivery of bioactive molecules to inhibit disease-producing cellular mechanisms. Selective drug delivery into target cells improves drug distribution and decreases dosing and toxicity.
Luís, Vasconcelos, Kalle, Pärn, Ulo, Langel   +2 more
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Classes and Prediction of Cell-Penetrating Peptides

2010
The classical view on how peptides enter cells has been changed due to the development in the research field of cell-penetrating peptides (CPPs). During the last 15 years, more than 100 peptide sequences have been published to enter cells and also to bring different biological cargoes with them.
Maria, Lindgren, Ulo, Langel
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Synthesis and Studies on Cell-Penetrating Peptides

Bioconjugate Chemistry, 2009
The ability of different synthetic cell penetrating peptides, as Antennapedia (wild and Phe(6) mutated penetratins), flock house virus, and integrin peptides to form complexes with a 25mer antisense oligonucleotide was compared and their conformation was determined by circular dichroism spectroscopy.
Jean-Remi, Bertrand, Claude, Malvy, Tiphanie, Auguste, Gábor K, Tóth, Orsolya, Kiss-Ivánkovits, Eszter, Illyés, Miklós, Hollósi, Sándor, Bottka, Ilona, Laczkó   +8 more
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Properties and Applications of Cell-Penetrating Peptides

2004
Cell-penetrating peptides (CPPs) are water-soluble molecules with sequences containing some cationic (basic) residues but have the ability to translocate through various cell plasma membranes with high efficiency and low lytic activity, and seemingly without any chiral receptor.
A, Gräslund, L E G, Eriksson
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Cell Penetrating Peptides in Drug Delivery

Pharmaceutical Research, 2004
Protein transduction domains (PTDs) are small cationic peptides that can facilitate the uptake of large, biologically active molecules into mammalian cells. Recent reports have suggested that PTDs may be able to mediate the delivery of cargo to tissues throughout a living organism.
Eric L, Snyder, Steven F, Dowdy
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Therapeutic Applications of Cell-Penetrating Peptides

2010
Since the discovery over 15 years ago of a protein transcription factor that possessed the ability to cross the plasma membrane, cell-penetrating peptides (CPPs) have been evaluated for the ability to transport diverse cargoes into cells, tissues, and organs.
Randolph M, Johnson, Stephen D, Harrison, Derek, Maclean   +2 more
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