Results 101 to 110 of about 5,562,033 (283)

Advances in Bio‐Integrated Edge Computing Systems for Smart and Connected Health

Advanced Materials, EarlyView.
This review explores advances in bio‐integrated edge computing for healthcare, focusing on co‐designing computing, sensing, and energy strategies to overcome integration and power challenges for optimized, decentralized operation. ABSTRACT Recent advances in bio‐integrated healthcare technologies have enabled continuous, high‐resolution monitoring and ...
Gyuwon Kim, Seungwon Yoo, Tae Woog Kang, Yunuo Huang, Woon‐Hong Yeo   +4 more
wiley   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Enzymatic activation of cell-penetrating peptides in self-assembled nanostructures triggers fibre-to-micelle morphological transition [PDF]

, 2017
Enzyme-assisted fibre-to-micelle transition in self-assembled nanostructures controls presentation of cell-penetrating peptides.
Yang Hu, Azevedo, HS, Lin, R, Cui, H, Yejiao Shi, Guy Ochbaum, Bitton, R, Ochbaum, G, Ran Lin, Hu, Y, Ronit Bitton, Honggang Cui, Helena S. Azevedo, Shi, Y   +13 more
core   +1 more source

Programmable Microgel Degradation in Dynamic Granular Hydrogels Guides Extracellular Matrix Assembly During Tissue Repair

Advanced Materials, EarlyView.
This study reports on the chemical modification of hyaluronic acid to create hydrogels with hydrolytic degradability ranging from 2–28 days. Granular hydrogels that undergo timed degradation to increase porosity enhance cell invasion and provisional ECM remodeling in a muscle injury model, leading to reduced fibrosis and improved regeneration ...
Zhiyuan Chen, Tuba Marjan, Xinyue Lu, Nicole E. Mertens, Keira Vesy, Dean E. Stornello, James F. Markworth, Taimoor H. Qazi   +7 more
wiley   +1 more source

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

Nature Communications, 2017
In vitroblood-brain barrier (BBB) models are crucial tools for screening brain-penetrating compounds. Here the authors develop a self-assembling BBB spheroid model with superior performance to the standard transwell BBB model, and use their platform to ...
Choi-Fong Cho, Justin M. Wolfe, Colin M. Fadzen, David Calligaris, Kalvis Hornburg, E. Antonio Chiocca, Nathalie Y. R. Agar, Bradley L. Pentelute, Sean E. Lawler   +8 more
doaj   +1 more source

Cell-Penetrating Peptides Containing Fluorescent d -Cysteines

, 2018
A series of fluorescent d-cysteines (Cys) has been synthesized and their optical properties were studied. The key synthetic step is the highly diastereoselective 1,4-conjugate addition of aryl thiols to a chiral bicyclic dehydroalanine recently developed
Gonzalo Jiménez-Osés, Ezcurra, B. [0000-0001-7211-2616], Avenoza, A. [0000-0002-5465-3555], Busto, J.H. [0000-0003-4403-4790], Compañón, I., Gutiérrez-Jiménez, M.I., Eva Gómez-Orte, Jesús H. Busto, Jesús M. Peregrina, Begoña Ezcurra, Ismael Compañón, Zurbano, M.M. [0000-0001-6370-3537], Juan Cabello, Jiménez-Osés, G. [0000-0003-0105-4337], Asín, A., Alberto Avenoza, Francisco Corzana, Marta I. Gutiérrez-Jiménez, Corzana, F. [0000-0001-5597-8127], Cabello, J. [0000-0002-3835-0116], Peregrina, J.M. [0000-0003-3778-7065], Claudio D. Navo, María M. Zurbano, Navo, C.D. [0000-0003-0161-412X], Alicia Asín, Gómez-Orte, E. [0000-0001-6802-1746]   +25 more
core   +1 more source

Tailored Cationic Visible‐Light‐Active Interfaces for Sustainable, Biodegradable Nanofibers With Dual‐Mode Antimicrobial Activity and Robust Electrostatic Particle Capture

Advanced Materials, EarlyView.
Surface co‐functionalization of biodegradable nanofibers with sodium copper chlorophyllin and quaternary ammonium compounds achieves synergistic antimicrobial activity through combined photodynamic and contact‐killing mechanisms. The cationic surface provides humidity‐resistant electrostatic particle capture while maintaining rapid enzymatic ...
Dong Uk Lee, Jae Hak Shin, Seung Yeon Lee, In Ho Kim, Jiho Choi, Joon Young Park, Sang Bok Kim, Jeong Sang Son, Sang Hun Kim, Jae Hee Jung, Dong Yun Choi   +10 more
wiley   +1 more source

The Uptake Mechanism of the Cell-Penetrating pVEC Peptide

Journal of Chemistry, 2013
Peptide based drug design efforts have gained renewed interest with the discovery of cargo-carrying or cell-penetrating peptides. Understanding the translocation mechanism of these peptides and identifying the residues or elements that contribute to ...
Ihsan Omur Akdag, Elif Ozkirimli
doaj   +1 more source

Cell-Penetrating Peptides Using Cyclic α,α-Disubstituted α‑Amino Acids with Basic Functional Groups

, 2018
In the delivery of cell-impermeable molecules, cell-penetrating peptides (CPPs) have been attracting increasing attention as intracellular delivery tools.
Takuma Kato (493431), Makoto Oba (338218), Koyo Nishida (1735597), Masakazu Tanaka (493432)   +3 more
core   +1 more source