Results 261 to 270 of about 61,199 (301)
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Trends in Pharmacological Sciences, 2000
The established view in cellular biology dictates that the cellular internalization of hydrophilic macromolecules can only be achieved through the classical endocytosis pathway. However, in the past five years several peptides have been demonstrated to translocate across the plasma membrane of eukaryotic cells by a seemingly energy-independent pathway.
M, Lindgren +3 more
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The established view in cellular biology dictates that the cellular internalization of hydrophilic macromolecules can only be achieved through the classical endocytosis pathway. However, in the past five years several peptides have been demonstrated to translocate across the plasma membrane of eukaryotic cells by a seemingly energy-independent pathway.
M, Lindgren +3 more
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Predicting cell-penetrating peptides
Advanced Drug Delivery Reviews, 2008Possibility to predict short peptide sequences capable to penetrate the plasma membrane opens new opportunities for developing peptide based intracellular delivery vectors, called cell-penetrating peptides (CPPs). Predictions of CPPs, however are often based on trial and error and may not always lead to new potent sequences.
Mats, Hansen, Kalle, Kilk, Ulo, Langel
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Cell‐Penetrating Peptides: Correlation between Peptide‐Lipid Interaction and Penetration Efficiency
ChemPhysChem, 2021AbstractCell‐penetrating peptides are used in the delivery of peptides and biologics, with some cell‐penetrating peptides found to be more efficient than others. The exact mechanism of how they interact with the cell membrane and penetrate it, however, remains unclear.
Fei Her Choong, Beow Keat Yap
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Intracellulartransduction using cell-penetrating peptides
Mol. BioSyst., 2010Cell penetrating peptides (CPPs), TATp, in particular, has been used widely for intracellular delivery of various agents ranging from small molecules to proteins, peptides, range of pharmaceutical nanocarriers and imaging agents. This review highlights the mechanisms of CPP-mediated delivery and summarizes numerous examples illustrating the potential ...
Rupa, Sawant, Vladimir, Torchilin
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Prediction of Cell-Penetrating Peptides
2015The in silico methods for the prediction of the cell-penetrating peptides are reviewed. Those include the multivariate statistical methods, machine-learning methods such as the artificial neural networks and support vector machines, and molecular modeling techniques including molecular docking and molecular dynamics.The applicability of the methods is ...
Mattias, Hällbrink, Mati, Karelson
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Proteomimetic Cell Penetrating Peptides
International Journal of Peptide Research and Therapeutics, 2008QSAR analysis of the primary sequence of human cytochrome c indicated that numerous putative cell penetrating peptide sequences are located within major amino- and carboxyl-terminal helical domains. Two such sequences, Cyt c77−101 and the shorter homologue Cyt c86−101, readily translocate the plasma membrane of U373MG astrocytoma cells but ...
John Howl, Sarah Jones
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Classes of Cell-Penetrating Peptides
2015During the three decades of cell-penetrating peptides era the superfamily of CPPs has rapidly expanded, and the quest for new sequences continues. CPPs have been well recognized by scientific community and they have been used for transduction of a wide variety of molecules and particles into cultured cells and in vivo.
Margus, Pooga, Ülo, Langel
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The Pharmacokinetics of Cell-Penetrating Peptides
Molecular Pharmaceutics, 2010Cell-penetrating peptides (CPPs) are able to penetrate the cell membrane carrying cargoes such as peptides, proteins, oligonucleotides, siRNAs, radioisotopes, liposomes, and nanoparticles. Consequently, many delivery approaches have been developed to use CPPs as tools for drug delivery.
Dikran, Sarko +8 more
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Cell-penetrating Peptide-mediated Nanovaccine Delivery
Current Drug Targets, 2021Vaccination with small antigens, such as proteins, peptides, or nucleic acids, is used to activate the immune system and trigger the protective immune responses against a pathogen. Currently, nanovaccines are undergoing development instead of conventional vaccines.
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pH-responsive PepFect cell-penetrating peptides
International Journal of Pharmaceutics, 2016A series of cell-penetrating PepFect peptide analogues was developed by substitutions of the galanin-derived N-terminal sequence. Histidine modifications were incorporated in order to make the peptides pH-responsive. The peptides were all able to form non-covalent complexes with an oligonucleotide cargo by co-incubation in buffer.
Regberg +5 more
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