Results 71 to 80 of about 61,199 (301)

Recent progress in mitochondria-targeted drug and drug-free agents for cancer therapy [PDF]

, 2019
The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions of the cell. Being a critical center of metabolic activities and involved in many diseases, mitochondria have been attracting attention as a potential target for
Jeena, M.T., Jin, Seongeon, Kim, Sangpil, Ryu, Ja-Hyoung   +3 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Cell-penetrating peptides for sustainable agriculture. [PDF]

Trends Plant Sci
Cell-penetrating peptides (CPPs) are short (typically 5-30 amino acids), cationic, amphipathic, or hydrophobic peptides that facilitate the cellular uptake of diverse cargo molecules by eukaryotic cells via direct translocation or endocytosis across the plasma membrane.
Patel P, Benzle K, Pei D, Wang GL.
europepmc   +4 more sources

Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics [PDF]

, 2018
Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available ...
Anderton, Ryan S, Knuckey, Neville W, MacDougall, Gabriella, Mastaglia, Frank L, Meloni, Bruno P   +4 more
core   +1 more source

Simple Model of the Transduction of Cell-Penetrating Peptides

, 2010
Cell-penetrating peptides (CPPs) such as HIV's trans-activating transcriptional activator (TAT) and polyarginine rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction.
Andrews, Bevers, Chen, Datta, Dom, Duchardt, Fischer, Frankel, Grandmaison, Green, Haase, Harbour, Herce, Hosotani, Jiang, K. Cahill, Kuge, Lipinski, Mai, Melikov, Mendoza, O'Shaughnessy, Parsegian, Prochiantz, Rostovtseva, Rothbard, Rothbard, Saito, Snyder, Snyder, Stone, Tang, Tünnemann, Tünnemann, Tünnemann, Tyagi, Voelker, Wadia, Willam, Zhou, Ziegler   +40 more
core   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging [PDF]

, 2008
Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru-Ahx-R5), and one to eight arginine residues, (Ru-Ahx-R8). Both complexes exhibit long-lived, intense, and oxygen sensitive luminescence.
Amoroso, Aylward, Bai, Brunner, Dobrucki, Fischer, Fuchs, Fuchs, Fulda, Futaki, Kale, Kielar, Kielar, Lakowicz, Lissi, Lo, Marc Devocelle, Mendoza, Mendoza, Murray, Musatkinaa, Niamh Moran, Pellegrin, Robert J. Forster, Santra, Tia E. Keyes, Ute Neugebauer, William Signac, Xu, Yann Pellegrin, Zhang, Zhong, Zhong   +32 more
core   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins

Frontiers in Microbiology, 2017
The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial peptides have been considered potential antibacterial drug leads. Using bioinformatic tools we have
Susana A. Dias, João M. Freire, João M. Freire, Clara Pérez-Peinado, Marco M. Domingues, Diana Gaspar, Nuno Vale, Paula Gomes, David Andreu, Sónia T. Henriques, Miguel A. R. B. Castanho, Ana S. Veiga   +11 more
doaj   +1 more source

Cell Penetrating Peptides, Novel Vectors for Gene Therapy

Pharmaceutics, 2020
Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first identified ~25 years ago, are small, 6−30 amino acid long, synthetic, or naturally occurring peptides, able to carry variety of cargoes across the cellular ...
Rebecca E. Taylor, Maliha Zahid
doaj   +1 more source