Results 121 to 130 of about 5,589,399 (306)

Methylmalonic Acid Impairs Cell Respiration and Glutamate Uptake in C6 Rat Glioma Cells: Implications for Methylmalonic Acidemia. [PDF]

Cell Mol Neurobiol, 2023
Costa RT, Santos MB, Alberto-Silva C, Carrettiero DC, Ribeiro CAJ.   +4 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Heightened mitochondrial respiration in CF cells is normalised by triple CFTR modulator therapy through mechanisms involving calcium

Heliyon
Background: Cystic fibrosis (CF) is associated with increased resting energy expenditure. However, the introduction of elexacaftor/tezacaftor/ivacaftor (ETI) has resulted in a paradigm shift in nutritional status for many people with CF, with increase ...
H.H. Jarosz-Griffiths, L.R. Caley, S. Lara-Reyna, S. Savic, I.J. Clifton, M.F. McDermott, D.G. Peckham   +6 more
doaj   +1 more source

Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes

Biology Open, 2017
The cytoskeletal architecture directly affects the morphology, motility, and tensional homeostasis of the cell. In addition, the cytoskeleton is important for mitosis, intracellular traffic, organelle motility, and even cellular respiration.
David H. Jang, Sarah C. Seeger, Martha E. Grady, Frances S. Shofer, David M. Eckmann   +4 more
doaj   +1 more source

SlipO2Chip - single-cell respiration under tuneable environments

In disciplines like toxicology and pharmacology, oxygen (O-2) respiration is a universal metric for evaluating the effects of chemicals across various model systems, including mammalian and microalgal cells.
Koren, Klaus,, Behrendt, Lars,, Whalen, Kristen E., Barbe, Laurent, Tenje, Maria,, Tenje, Maria, Barbe, Laurent,, Shi, Qian,, Whalen, Kristen E.,, Cui, Yuan, Koren, Klaus, Behrendt, Lars, Shi, Qian, Moreira, Milena,, Cui, Yuan,, Moreira, Milena   +15 more
core   +1 more source

Soil respiration in a northeastern US temperate forest: a 22-year synthesis [PDF]

, 2013
To better understand how forest management, phenology, vegetation type, and actual and simulated climatic change affect seasonal and inter-annual variations in soil respiration (Rs), we analyzed more than 100,000 individual measurements of soil ...
Foster, D.R., Ollinger, Scott, Munger, J. William, Steudler, P.A., Bowden, Richard D., Varner, R.K., Crill, P.M., Frey, Serita D., Tang, Jiang, Giasson, Marc-Andre, Davidson, Eric A., Drake, John E., Nicoll, L., Savage, Kathleen E., Lavine, M., Finzi, Adrien C., Nadelhoffer, Knute, Wofsy, S.C, Ellison, Aaron M., Hadley, J.L., Melillo, Jerry M.   +20 more
core   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

, 2010
SummaryA mild inhibition of mitochondrial respiration extends the life span of many organisms, including yeast, worms, flies, and mice [1–10], but the underlying mechanism is unknown.
Seung-Jae Lee, Ara B. Hwang, Cynthia Kenyon, Lee, SJ, Kenyon, C, Hwang, AB   +5 more
core   +2 more sources

Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

, 2020
Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key negative regulator of interleukin-15 (IL-15) signaling in natural killer (NK) cells.
Kaufman, Dan S, Malmberg, K-J, Ask, Eivind Heggernes, Meng, Z, Blum, Robert H, Blum, RH, Guan, K-L, Hoel, HJ, Blum, Robert H., Zhu, H, Wu, C, Zhu, Huang, Wu, Chengsheng, Bernareggi, D, Hoel, Hanna Julie, Bernareggi, Davide, Malmberg, Karl-Johan, Kaufman, Dan S., Wu, Zhengming, Wu, Z, Guan, Kun-Liang, Meng, Zhipeng, Ask, EH   +22 more
core   +1 more source