Results 141 to 150 of about 5,589,399 (306)

Combination of arsenic trioxide and apatinib synergistically inhibits small cell lung cancer by down-regulating VEGFR2/mTOR and Akt/c-Myc signaling pathway via GRB10

Hereditas
Background Small cell lung carcinoma (SCLC) is characterized by -poor prognosis, -high predilection for -metastasis, -proliferation, and -absence of newer therapeutic options.
Yao Yu, Yu Shang, Si Shi, Yaowu He, Wenchao Shi, Menghan Wang, Qi Wang, Dandan Xu, Ce Shi, Hong Chen   +9 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Drosophila melanogaster Sperm under Simulated Microgravity and a Hypomagnetic Field: Motility and Cell Respiration. [PDF]

Int J Mol Sci, 2020
Ogneva IV, Usik MA, Burtseva MV, Biryukov NS, Zhdankina YS, Sychev VN, Orlov OI.   +6 more
europepmc   +1 more source

Suppressing mitochondrial respiration is critical for hypoxia tolerance in the fetal growth plate

, 2019
Oxygen (O2) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1α (Hif1a), a mediator of the cellular adaptation to low O2 tension (hypoxia). Hypoxic cells require Hif1a to survive.
Vemulapalli K., Mangiavini L., Khan M. P., LaGory E. L., Tata Z., Merceron C., Hu J., Giaccia A. J., Chandel N. S., Yao Q., Schipani E.   +10 more
core   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Progesterone restores mitochondrial bioenergetic function in streptozotocin- and amyloid-β-challenged HT-22 hippocampal cells: An in vitro model of Alzheimer's disease

Journal of Alzheimer's Disease Reports
Background Mitochondrial dysfunction contributes to Alzheimer's disease (AD) by promoting bioenergetic failure and neuronal loss. Objective We investigated whether progesterone (P4) protects against mitochondrial impairment in two in vitro AD models ...
Seema Yousuf, Fahim Atif, Donald G. Stein   +2 more
doaj   +1 more source

Protocol for measuring mitochondrial respiratory capacity from buccal cell swabs

STAR Protocols
Summary: Mitochondrial respirometry provides a detailed assessment of oxygen consumption within the electron transport system, yet methods detailing respiration from non-invasive samples remain limited.
Tina R. Ram, Chunlong Mu, Jaclyn C. Campbell, Sarah J. MacEachern, Jane Shearer   +4 more
doaj   +1 more source

Substrates used in SIR assays can inhibit basal respiration in rewetted soil [PDF]

, 2010
Respiration assays are routinely used for investigating microbial metabolic activity in soil, but usually after a period of "conditioning" whereby dry soil is rewetted and incubated for a period of days.
Archibald, R., Bialkowski, K.M., Hardy, G.E.St.J., Burgess, T.I.   +3 more
core