Results 131 to 140 of about 5,235,766 (308)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Cell Respiration—Energy Production of Cells [PDF]

Advances in Social Science, Education and Humanities Research, 2022
openaire   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Changes of Respiration Activities in Cells of Winter Wheat and Sugar Cane Suspension Cultures During Programmed Cell Death Process [PDF]

Journal of Stress Physiology & Biochemistry, 2015
Process of cell death in suspension cultures of winter wheat and sugar cane under high (50 °С) and negative (-8 °С) temperature treatment has been studied.
I.V. Lyubushkina, A.V. Fedyaeva, A.V. Stepanov, T.P. Pobezhimova   +3 more
doaj  

The Cell and energy

, 1988
Examines the cell's energy molecule, glucose. Also illustrates the cell respiration process of extracting energy from glucose and transferring it to ATP in specific organelles.Narrator, James Moriarty ; consultant, Bob ...

core  

Substrates used in SIR assays can inhibit basal respiration in rewetted soil [PDF]

, 2010
Respiration assays are routinely used for investigating microbial metabolic activity in soil, but usually after a period of "conditioning" whereby dry soil is rewetted and incubated for a period of days.
Archibald, R., Bialkowski, K.M., Hardy, G.E.St.J., Burgess, T.I.   +3 more
core  

From breathing to respiration.

, 2015
The purpose of breathing remained an enigma for a long time. The Hippocratic school described breathing patterns but did not associate breathing with the lungs. Empedocles and Plato postulated that breathing was linked to the passage of air through pores
Fitting, J.W.
core   +1 more source

Protocol for measuring mitochondrial respiratory capacity from buccal cell swabs

STAR Protocols
Summary: Mitochondrial respirometry provides a detailed assessment of oxygen consumption within the electron transport system, yet methods detailing respiration from non-invasive samples remain limited.
Tina R. Ram, Chunlong Mu, Jaclyn C. Campbell, Sarah J. MacEachern, Jane Shearer   +4 more
doaj   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Drosophila melanogaster Sperm under Simulated Microgravity and a Hypomagnetic Field: Motility and Cell Respiration. [PDF]

Int J Mol Sci, 2020
Ogneva IV, Usik MA, Burtseva MV, Biryukov NS, Zhdankina YS, Sychev VN, Orlov OI.   +6 more
europepmc   +1 more source