Results 31 to 40 of about 829,143 (266)
The Shaping of the T Cell Repertoire [PDF]
Immunity, 2001 By combining a TCRbeta transgene with a TCRalpha minilocus comprised of a single V and two J gene segments, we engineered a mouse line exhibiting ample but focused TCR diversity, restricted to CDR3alpha. Using single-cell PCR and high-throughput sequencing, we have exploited this system to scrutinize T cell repertoire selection and evolution.
Correia-Neves, Margarida +3 more
openaire +2 more sources
Aggregate Filamentous Growth Responses in Yeast
mSphere, 2019 Many fungal species, including pathogens, undergo a morphogenetic response called filamentous growth, where cells differentiate into a specialized cell type to promote nutrient foraging and surface colonization.
Jacky Chow +7 more
doaj +1 more source
3D Organisation of Cells in Pseudostratified Epithelia
Frontiers in Physics, 2022 Pseudostratified epithelia have smooth apical and basal surfaces, yet along the apical-basal axis, cells assume highly irregular shapes, which we introduce as punakoids. They interact dynamically with many more cells than visible at the surface. Here, we
Dagmar Iber +3 more
doaj +1 more source
Conserved cellular patterning in the mesophyll of rice leaves
Plant Direct, 2023 The mesophyll cells of grass leaves, such as rice, are traditionally viewed as displaying a relatively uniform pattern, in contrast to the clear distinctions of palisade and spongy layers in typical eudicot leaves. This quantitative analysis of mesophyll
Jen Sloan +7 more
doaj +1 more source
Cell Shape: Taking the Heat [PDF]
Current Biology, 2008 Preservation of cell architecture under physically stressful conditions is a basic requirement for many biological processes and is critical for mechanosensory systems built to translate subtle changes in cell shape into changes in organism behaviour. A new study reveals how an extracellular protein--Spam--helps mechanosensory organs in the fruit fly ...
Kunda, Patricia +2 more
openaire +2 more sources
Frontiers in Microbiology, 2023 Haloferax volcanii and other Haloarchaea can be pleomorphic, adopting different shapes, which vary with growth stages. Several studies have shown that H.
Megha Patro +4 more
doaj +1 more source
Microbiology Spectrum, 2023 Peptidoglycan (PG) is an essential bacterial architecture pivotal for shape maintenance and adaptation to osmotic stress. Although PG synthesis and modification are tightly regulated under harsh environmental stresses, few related mechanisms have been ...
Umji Choi +4 more
doaj +1 more source
Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina
Frontiers in Cell and Developmental Biology, 2023 Introduction: Nuclei have characteristic shapes dependent on cell type, which are critical for proper cell function, and nuclei lose their distinct shapes in multiple diseases including cancer, laminopathies, and progeria.
Richard B. Dickinson +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks +5 more
wiley +1 more source