Results 231 to 240 of about 5,689,979 (299)

A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations. [PDF]

PLoS Comput Biol
Vanoni M, Palumbo P, Papa F, Busti S, Gotti L, Wortel M, Teusink B, Orlandi I, Pessina A, Airoldi C, Brambilla L, Vai M, Alberghina L.   +12 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Swi4-dependent SWI4 transcription couples cell size to cell cycle commitment. [PDF]

iScience
Goswami P, Ghimire A, Coffin C, Cheng J, Coulombe-Huntington J, Ghazal G, Thattikota Y, Guerra MF, Tyers M, Tollis S, Royer CA.   +10 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Harnessing cell size to separate genetically and functionally distinct dental pulp-derived mesenchymal stromal cell subpopulations. [PDF]

J Biol Eng
Jiang Y, Zhang Z, Ren K, Zhou S, Qiao Y, Huang W, Zhang N, Xu H, Xu X, Wen B, Zhang W, Yin L.   +11 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Heat shock transcription factor-mediated thermal tolerance and cell size plasticity in marine diatoms. [PDF]

Nat Commun
Huang D, Cheng CQ, Zhang HY, Huang Y, Li SY, Huang YT, Huang XL, Pei LL, Luo Z, Zou LG, Yang WD, Zheng XF, Li DW, Li HY.   +13 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Cell size explains shift in phytoplankton community structure following storm-induced changes in light and nutrients. [PDF]

Ecology
Guislain ALN, Nejstgaard JC, Köhler J, Sperfeld E, Mischke U, Skjelbred B, Grossart HP, Lyche Solheim A, Gessner MO, Berger SA.   +9 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source