INCREASED SURVIVAL IN MICE INOCULATED WITH TUMOR CELLS AND TREATED WITH INTERFERON PREPARATIONS [PDF]
, 1969 Ion Gresser +4 more
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Protective Effects of Insulin in Cardiomyocytes Against Iron-mediated Cell Death
, 2019 When an acute myocardial infarction (MI) occurs, the heart becomes ischemic. Medical treatments such as stents have improved the recovery process after a MI, but there is still a high risk for heart failure.
Matsui, M.D., Ph.D., FAHA, Takashi +1 more
core
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Red Blood Cell Survival in Patients with Aortic Valvular Disease and Ball-Valve Prostheses [PDF]
, 1965 Michael Brodeur +5 more
openalex +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages
Journal of Lipid Research, 2004 It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts (Gómez-Muñoz, A., P. A. Duffy, A. Martin, L. O'Brien, H-S. Byun, R. Bittman, and D. N. Brindley. 1995. Mol. Pharmacol. 47: 883–889; Gómez-Muñoz, A., L. M.
Antonio Gómez-Muñoz +3 more
doaj
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
THE DIFFERING SURVIVAL OF NORMAL AND SENSITIZED SPLEEN CELLS TRANSFERRED TO ALLOGENEIC HOSTS [PDF]
, 1964 Brack Hattler +2 more
openalex +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Editorial: Molecular Mechanisms of Selective Autophagy in Human Disease
Frontiers in Cell and Developmental Biology, 2020 Valentina Cianfanelli +2 more
doaj +1 more source