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Neoplastic transformation of human cells in vitro.
Critical reviews in oncogenesis, 1993Efforts to investigate the progression of events that lead normal human cells in culture to become neoplastic in response to carcinogenic agents have been aided by the development of the suitable in vitro model systems. For initial human cell transformation studies, a flat, nontumorigenic clonal line, originally derived from a human osteosarcoma (HOS),
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Positive Mediators of Cell Proliferation in Neoplastic Transformation
2002Cancer is not a single disease, but a collection of diseases all of which are related by a common root cause: the loss of controlled cell growth. Cancer begins as a clonal disease, that is, it stems from the genetic corruption of a single cell. This conversion of a normal cell into the neoplastic state is a multi-step phenomenon called neoplastic ...
James N. Welch, Susan A. Chrysogelos
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Neoplastic cell transformation by energetic heavy ions and its modification with chemical agents.
Advances in Space Research, 1984T. Yang, C. Tobias
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Heterochromatin, Satellite DNA, and Transformed Neoplastic Cells
JNCI: Journal of the National Cancer Institute, 1972N C, Popescu, J A, DiPaolo
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Radiation-Induced Neoplastic Transformation of Human Cell Hybrids
1987In vitro cell systems are well established in the study of mechanisms of neoplastic transformation by a variety of agents including chemicals, ultraviolet light and ionizing radiation (for recent reviews see references 1-4). However, with few exceptions, systems that are used for quantitative studies are rodent-derived cell lines, usually of ...
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Relationship of chromosome changes to neoplastic cell transformation.
The American journal of pathology, 1977Chromosomal abnormalities are a frequent concomitant of neoplasia, and although it is tempting to relate these mutations and alterations in chromatin (DNA) function to cancer, their relationship to the initiation or progression of carcinogenesis is unknown.
J A, DiPaolo, N C, Popescu
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Tracheal epithelial cell transformation: a model system for studies on neoplastic progression.
Critical Reviews in Toxicology, 1984P. Nettesheim +2 more
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