Results 181 to 190 of about 633,194 (250)
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Neoplastic cell transformation by heavy ions.
Radiation Research, 1989We have studied the induction of morphological transformation by heavy ions. Golden hamster embryo cells were irradiated with 95 MeV 14N ions (530 keV/microns), 22 MeV 4He ions (36 keV/microns), and 22 MeV 4He ions with a 100-microns Al absorber (77 keV/microns) which were generated by a cyclotron at the Institute of Physical and Chemical Research in ...
M. Suzuki +4 more
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Neoplastic cell transformation by high-LET radiation: molecular mechanisms.
Advances in Space Research, 1989Experimental data on molecular mechanisms are essential for understanding the bioeffects of radiation and for developing biophysical models, which can help in determining the shape of dose-response curves at very low doses, e.g., doses less than 1 cGy. Although it has been shown that ionizing radiation can cause neoplastic cell transformation directly,
Tracy Chui-hsu Yang +3 more
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Carcinogen-induced Cellular Thesaurismoses and Neoplastic Cell Transformation
, 1973It has been known for a long time from human pathology that many tumors contain cells which store polysaccharides or lipids. So far such pathological storage phenomena have been interpreted as a consequence of the neoplastic cell transformation and to be related to the general disturbance of tumor cell metabolism.
P. Bannasch
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Cell surface protein and neoplastic transformation
Trends in Biochemical Sciences, 1976A major fibroblast glycoprotein that is diminished after malignant transformation has been isolated and partially characterized. Reconstitution experiments indicate that the glycoprotein helps maintain normal cell shape, adhesion, and contact inhibition of movement.
Kenneth M. Yamada, Ira Pastan
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The Neoplastic Transformation of SCID Cells by Radiation
Radiation Research, 1999Severe combined immunodeficiency (SCID) cells are hypersensitive to killing by ionizing radiation because of deregulation of DNA-dependent protein kinase (DNA-PK) and a concomitant deficiency in the repair of DNA double-strand breaks. The effect of this condition on the neoplastic transformation of SCID fibroblasts, designated SCID 3T1, has been ...
M, Lun +4 more
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Neoplastic transformation of primary tracheal epithelial cell cultures
Carcinogenesis, 1983Primary cultures of rat tracheal epithelial cells were treated with the chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) to quantitatively study the early events during neoplastic transformation. Epithelial cells were dissociated from tracheas of specific-pathogen-free Fischer-344 rats and were plated on collagen-coated tissue culture ...
S B, Pai, V E, Steele, P, Nettesheim
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Quantitative Neoplastic Transformation in C3H/10T1/2 Cells
1985The development of mammalian cell culture systems in which neoplastic transformation can be induced by exposure to chemical and physical carcinogens provided a major stimulus to the study of carcinogenic mechanisms. Furthermore, the potential ability to quantitate the induction of neoplasia on a per cell basis has allowed the study of factors ...
J S, Bertram, J E, Martner
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Epigenetic Transformation by RNA from Human Neoplastic Cells
Oncology, 1973The study of biologic properties of nucleic acids from either normal or malignant cells transcends the search for subviral infectivity. The differing results obtained in studying the behavior of nucleic acids from human malignant cells on primary cultures are critically reviewed in the light of the methodology involved.
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Transforming growth factors and control of neoplastic cell growth
Journal of Cellular Biochemistry, 1987AbstractTransforming growth factors (TGFs) are peptides that affect the growth and phenotypic of cultured cells and bring about in nonmalignant fibroblastic cells phenotypic properties that resemble those of malignant cells. Two types of TGFs have been well characterized.
J, Keski-Oja +4 more
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Cell Surfaces in Neoplastic Transformation
1971Publisher Summary This chapter describes the properties, and the chemical and physiological aspects of cell surfaces in neoplastic transformation. Immunological surface disparities between normal and tumor cells have been studied for decades, while attempts to bring them into the realm of biochemistry have been extremely rare.
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