Results 201 to 210 of about 328,446 (262)

Viral Transformation of Epithelial Cells

2012
Approximately 18% of human cancers have a viral etiology and the majority of these involve transformation of epithelial cells. Viral proteins transform epithelia by inducing alterations in the normal cell growth and differentiation pathways through the targeting of host proteins.
Jennifer A, Regan, Laimonis A, Laimins
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Cell Transformation by the Viral src Oncogene

Annual Review of Cell Biology, 1987
PERSPECTIVES AND SUMMARy . .... . . ... ......... . . . . . . . . .. . . . . 31 OVERVIEW OF CELL TRANSFORMATION . .. ..... . ......... . . .. ". . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 ORIGIN OF VIRAL src . ..... ..... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .....
R, Jove, H, Hanafusa
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The viral genome in transformed cells

Proceedings of the Royal Society of London. Series B. Biological Sciences, 1971
Abstract Polyoma and SV 40-transformed cells carry multiple copies of the entire genome in their chromosomes; the viral DNA sequences appear to be covalently integrated into the host cell’s DNA but it is not known whether they are clustered in a reiterated tandem sequence or whether they are distributed singly or in clusters ...
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Cell-Driven Viral Transformation

1985
Since the advent of hybridoma technology, one of the most provocative applications for monoclonal antibodies has been immunotherapy. Early reports of experiments performed in mice suggested that monoclonal antibody therapy was beneficial against murine T-cell lymphoma (Bernstein et al., 1980) and that it might be useful to deliver potent toxins to ...
Anthony W. Siadak, Mark E. Lostrom
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Increment of DNA topoisomerases in chemically and virally transformed cells

Experimental Cell Research, 1988
The activities of topoisomerases I and II were assayed in subcellular extracts obtained from nontumorigenic BALB/c 3T3 A31 and normal rat kidney (NRK) cell lines and from the same cells transformed by benzo[a]pyrene (BP-A31), Moloney (M-MSV-A31) and Kirsten (K-A31) sarcoma viruses, and simian virus 40 (SV-NRK). The enzymatic activity of topoisomerase I
M D, Crespi, A G, Mladovan, A, Baldi
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SELECTIVE KILLING OF TRANSFORMED CELLS BY A VIRAL CYTOTOXIC PRODUCT

Biochemical Society Transactions, 1996
info:eu-repo/semantics ...
Mousset, Suzanne, Anouja, Fatima, Op De Beeck, Anne, Caillet Fauquet, Perrine   +3 more
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Viral Transformation of Monkey Kidney Cell Cultures

Nature, 1967
Simian tumour virus SV40 induces transformation of primary cultures of cercopithecus monkey kidney cells. The cells become highly vacuolated, complement fixing viral antigen is formed and the cells become resistant to the cytopathic effects of the virus. It is probable that a persistent association develops between the cells and the virus genome.
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An altered response of virally transformed 3T3 cells to ouabain

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1978
The effect of ouabain on K+ transport was examined in 3T3 and virally transformed 3T3 cells. A 10 min exposure to ouabain (10(-3) M) produced approximately 40% inhibition of the unidirectional K+ influx in all cell lines. In 3T3 cells the response was not significantly altered by up to 70 min exposure to the drug. In contrast, the continued exposure of
K D, Brown, J F, Lamb
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On the reduced intercellular adhesiveness of virally transformed BHK21 cells

Journal of Cell Science, 1979
ABSTRACT Baby hamster kidney fibroblasts (BHK21 cells) transformed by polyoma or Rous sarcoma viruses aggregate less than the untransformed parental cells when incubated in growth medium in a gyratory shaker for 18–24 h. This difference can be measured by electronic particle counting, or by filtering aggregated suspensions of 32 P ...
J G, Edwards, J M, Dysart, D H, Edgar, R T, Robson   +3 more
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Proteolytic Enzymes, Cell Surface Changes, and Viral Transformation

1976
Publisher Summary This chapter reviews the evidence for and against the view that proteolysis plays a role in determining some of the phenotypic characteristics of virus-transformed cells. It discusses some aspects of the structure of the cellular membrane surface because one possible mechanism by which proteases might alter cell properties is via ...
R, Robin, I N, Chou, P H, Black
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