Results 101 to 110 of about 1,789,995 (350)

Rational treatment selection for primary Merkel Cell Carcinoma: a Rational MCC RCT comparing surgery and radiotherapy with parallel observational study

Efficacy and Mechanism Evaluation
Background Merkel cell carcinoma is a rare locally invasive skin cancer of older people. Standard management for primary Merkel cell carcinoma is surgery and/or radiotherapy, with no standard of care or unity of practice, based on retrospective ...
Neil M Steven, Sarah Pirrie, Yolande Jefferson-Hulme, Claire H Gaunt, Victoria Homer   +4 more
doaj   +1 more source

Sialidase Activity in Transformed Cells

Journal of Biological Chemistry, 1973
Abstract Sialidase activity, ganglioside patterns, and total cellular sialic acid content were determined for normal and transformed hamster cells in tissue culture. Sialidase activity toward added extracellular disialo- and trisialoganglioside substrate was found in all transformed cell lines studied.
C L, Schengrund, R N, Lausch, A, Rosenberg   +2 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Native Plasmid-Encoded Mercury Resistance Genes Are Functional and Demonstrate Natural Transformation in Environmental Bacterial Isolates. [PDF]

, 2019
Plasmid-mediated horizontal gene transfer (HGT) is a major driver of genetic diversity in bacteria. We experimentally validated the function of a putative mercury resistance operon present on an abundant 8-kbp native plasmid found in groundwater samples ...
Carlson, Hans K, Deutschbauer, Adam M, Kothari, Ankita, Mukhopadhyay, Aindrila, Soneja, Drishti, Tang, Albert   +5 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Mechanisms of cell transformation induced by polyomavirus

Brazilian Journal of Medical and Biological Research, 1999
Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis.
M.L.S. Oliveira, S.M. Brochado, M.C. Sogayar   +2 more
doaj   +1 more source

Orthovanadate, an inhibitor of protein tyrosine phosphatases, acts more potently as a promoter than as an initiator in the BALB/3T3 cell transformation [PDF]

, 1997
Ayako Sakai
openalex   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Renormalization group approach to an Abelian sandpile model on planar lattices

, 2002
One important step in the renormalization group (RG) approach to a lattice sandpile model is the exact enumeration of all possible toppling processes of sandpile dynamics inside a cell for RG transformations. Here we propose a computer algorithm to carry
A. Corral, A. Sornette, A. Vespignani, A. Vespignani, B. Drossel, B.D. Malamud, C. Tebaldi, C.-K. Hu, C.-K. Hu, C.-K. Hu, C.-K. Hu, C.-K. Hu, C.-K. Hu, C.-K. Hu, C.-K. Hu, C.-Y. Lin, Chai-Yu Lin, Chin-Kun Hu, D. Dhar, D. Dhar, D. Dhar, D.V. Ktiarev, E.V. Ivashkevich, E.V. Ivashkevich, E.V. Ivashkevich, J. Hasty, K. Chen, K. Christensen, L. Pietronero, P. Bak, P. Bak, P. Bak, R.V. Sole, S. Lübeck, S.N. Majumdar, S.S. Manna, S.S. Manna, S.S. Manna, S.S. Manna, S.S. Manna, S.S. Manna, V. Frette, V.B. Priezzhev, V.B. Priezzhev, V.B. Priezzhev, Vl.V. Papoyan, Y. Moreno   +46 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source