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La Revue du praticien, 1996
The use of in vitro cell transformation, as a complement to the direct study of tumors and established tumor cell lines, has enabled the analysis of the contribution of diverse genes to the tumor phenotype. The most recent results have underlined the importance of fundamental mechanisms regulating cell proliferation.
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The use of in vitro cell transformation, as a complement to the direct study of tumors and established tumor cell lines, has enabled the analysis of the contribution of diverse genes to the tumor phenotype. The most recent results have underlined the importance of fundamental mechanisms regulating cell proliferation.
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Mitochondrial transformation of mammalian cells
Nature, 1982Resistance to the antibiotics chloramphenicol (CAPr) and efrapeptin (EFr) in mammalian cells is cytoplasmically inherited1,2. We demonstrate here that purified mitochondria obtained from CAPr and EFr cells are taken up by endocytosis and transfer antibiotic resistance to chloramphenicol-(CAPs) and efrapeptin-(EFs) sensitive cells.
M A, Clark, J W, Shay
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Evaluating virus-transformed cell tumorigenicity
Journal of Virological Methods, 1999The tumorigenicity of adenovirus (Ad) 12-transformed mouse cells was evaluated by analyzing the relationship of tumor cell dose to tumor incidence and tumor latency. The tumor producing dose 50% endpoint values used to define these relationships remained stable during 52 weeks of serial passage in tissue culture and were not determined by low frequency
A M, Lewis +4 more
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1979
A number of cell culture systems have been developed over the past ten years in which normal or non-malignant cells have been changed (‘transformed’) with respect to various test markers, including malignancy in the whole animal, following injection of the cells after exposure in vitro to chemical carcinogens. The prime purpose of these methods was the
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A number of cell culture systems have been developed over the past ten years in which normal or non-malignant cells have been changed (‘transformed’) with respect to various test markers, including malignancy in the whole animal, following injection of the cells after exposure in vitro to chemical carcinogens. The prime purpose of these methods was the
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Mutagensis and cell transformation in cell culture
Methods in Cell Science, 1999The current lack of continuous prawn cell lines suitable for the isolation and growth of prawn viruses is a major setback for diagnosis of viral diseases of prawns; isolation and identification of the causative agents are severely hindered and the development of other diagnostic procedures is slowed.
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Reversion in virus-transformed cells
Biochemical Pharmacology, 1971Abstract The hamster cell line BHK21 can be transformed by the Schmidt-Ruppin strain of Rous sarcoma (RSV-SR) and by polyoma viruses. Revertant cells that have apparently lost the virus genes can be obtained in both cases. These occur spontaneously in the case of RSV-SR transformed cells and following the induction of chromosome loss from near ...
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DNA Transformation of Mammalian Cells
2003The manipulation of gene sequences between cells is a fundamental technique in genetics. Mammalian cells will take up and express genes when they are exposed to either metaphase chromosomes or naked genomic or recombinant DNA. In each case the uptake and expression is enhanced by the formation of a DNA-calcium phosphate precipitate (1,2). Alternatively,
J W, Pollard +3 more
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Physiology of transformed glial cells
Glia, 1995AbstractMuch of our present knowledge of glial cell function stems from studies of glioma cell lines, both rodent (C6, C6 polyploid, and TR33B) and human (1321N1, 138MG, D384, R‐111, T67, Tp‐301MG, Tp‐483MG, Tp‐378MG, U‐118MG, U‐251MG, U‐373MG, U‐787MG, U‐1242MG, and UC‐11MG). New methods such as patch clamp and Ca2+ imaging have lead to rapid progress
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1979
Publisher Summary This chapter focuses on cell transformation. A “transformed” cell is one that has undergone a stable hereditable change that enables it to grow into a tumor in an appropriate recipient animal. Nude mice have an immunological deficiency that interferes with their ability to reject foreign cells, thereby allowing their use for ...
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Publisher Summary This chapter focuses on cell transformation. A “transformed” cell is one that has undergone a stable hereditable change that enables it to grow into a tumor in an appropriate recipient animal. Nude mice have an immunological deficiency that interferes with their ability to reject foreign cells, thereby allowing their use for ...
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