Results 121 to 130 of about 13,969,136 (421)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Conditioned Unitary Transformation on biphotons

, 2003
A conditioned unitary transformation ($90^o$ polarization rotation) is performed at single-photon level. The transformation is realized by rotating polarization for one of the photons of a polarization-entangled biphoton state (signal photon) by means of
A. A. Malygin, A. A. Malygin, D. Boschi, D. N. Klyshko, D. N. Klyshko, D. N. Klyshko, G. Brida, L. A. Krivitsky, M. Genovese, M. Gramegna, M. V. Chekhova, S. P. Kulik, T. Jennewein   +12 more
core   +1 more source

Transformation of Lung Squamous Cell Carcinoma to Small Cell Lung Cancer After Immunotherapy Resistance: A Case Report

Cancer Management and Research, 2023
Diming Wang,1,* Wei Ye,2,* Dongmei Chen,1 Qingming Shi,1 Dongchun Ma3 1Department of Oncology, Anhui Chest Hospital, Hefei, 230022, People’s Republic of China; 2Department of Pathology, Anhui Chest Hospital, Hefei, 230022, People’s Republic of ...
Wang D, Ye W, Chen D, Shi Q, Ma D
doaj  

Development of pediatric myeloid leukemia may be related to the repeatedbone-remodeling during bone-growth [PDF]

arXiv, 2018
Acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) are two major formsof leukemia developed from myeloid cells (MCs). To understand why AML and CML occurin children, we analyzed the causes and the mechanism of cell transformation of a MC. I.
arxiv  

Droplet electroporation in microfluidics for efficient cell transformation with or without cell wall removal.

Lab on a Chip, 2012
An efficient cell transformation method is presented that utilizes droplet electroporation on a microfluidic chip. Two types of green microalgae, a wall-less mutant and a wild type of Chlamydomonas reinhardtii, are used as model cells.
Baiyan Qu, Y. Eu, W. Jeong, Dong‐Pyo Kim   +3 more
semanticscholar   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Epicardial cell transformation

The FASEB Journal, 2010
The embryonic epicardium, which invests all the heart surface by midgestation, derives from an extracardiac progenitor tissue called the proepicardium. The embryonic epicardium gives rise to a population of mesenchymal cells called the epicardially‐derived cells (EPDCs) that populate the space between the myocardium and the epicardium and later invade ...
openaire   +1 more source

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. [PDF]

, 2015
BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis ...
Borowsky, AD, Cardiff, RD, Hovey, RC, Manjarin, R, Rowson-Hodel, AR, Trott, JF   +5 more
core  

Transformation from Small Cell to Squamous Cell Carcinoma in a Thymic Carcinoma Patient with a Durable Response to Anlotinib: A Case Report

Cancer Management and Research, 2022
Wenru Qin,1,2,* Bing Zou,2,* Xinyu Fan,2,3 Bingjie Fan,2 Shijiang Wang,2 Linlin Wang2 1Department of Oncology, Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Department of Radiation Oncology, Shandong Cancer Hospital ...
Qin W, Zou B, Fan X, Fan B, Wang S, Wang L   +5 more
doaj  

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source