Results 131 to 140 of about 13,969,136 (421)
Cell Type Identification from Single-Cell Transcriptomic Data via Semi-supervised Learning [PDF]
arXiv, 2020 Cell type identification from single-cell transcriptomic data is a common goal of single-cell RNA sequencing (scRNAseq) data analysis. Neural networks have been employed to identify cell types from scRNAseq data with high performance. However, it requires a large mount of individual cells with accurate and unbiased annotated types to build the ...
arxiv
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Three pathways of cell transformation of lymphoid cell: a slow, a rapid, and an accelerated [PDF]
arXiv, 2018 Lymphoid leukemia (LL) and lymphoma are neoplasms developed from lymphoid cells (LCs). To understand why different forms of LL/lymphoma occur at different ages, we analyzed the effects of different types of DNA changes on a LC and the cellular characteristics of LCs. Point DNA mutations (PDMs) and chromosome changes (CCs) are the two major types of DNA
arxiv
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
In vitro investigation of the effects of X- rays carried by a photon beam upon the cell cycle progression in Vero cells [PDF]
arXiv, 2013 The effects of the X-rays carried out in a photon beam produced by a medical linear particle accelerator on the progression of the cell cycle in normal cells Vero were evaluated by flow cytometric mean. The evaluation of the consequences of 1 and 3 Gy irradiation upon cell cycle development was performed after 96 and 120 hours from the exposure moment,
arxiv
Cognitive computation using neural representations of time and space in the Laplace domain [PDF]
arXiv, 2020 Memory for the past makes use of a record of what happened when---a function over past time. Time cells in the hippocampus and temporal context cells in the entorhinal cortex both code for events as a function of past time, but with very different receptive fields.
arxiv
Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation
Journal of Biological Chemistry, 2011 Autophagy has recently been implicated in both the prevention and progression of cancer. However, the molecular basis for the relationship between autophagy induction and the initial acquisition of malignancy is currently unknown.
Min-Jung Kim +8 more
semanticscholar +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Sialidase Activity in Transformed Cells
Journal of Biological Chemistry, 1973 Abstract Sialidase activity, ganglioside patterns, and total cellular sialic acid content were determined for normal and transformed hamster cells in tissue culture. Sialidase activity toward added extracellular disialo- and trisialoganglioside substrate was found in all transformed cell lines studied.
Abraham Rosenberg +2 more
openaire +3 more sources
PLoS Computational Biology, 2014 Recently, a molecular pathway linking inflammation to cell transformation has been discovered. This molecular pathway rests on a positive inflammatory feedback loop between NF-κB, Lin28, Let-7 microRNA and IL6, which leads to an epigenetic switch ...
Claude Gérard +3 more
doaj +1 more source