Results 51 to 60 of about 13,969,136 (421)
Transformation of Epidermal Cells in Culture
Journal of Investigative Dermatology, 1983 Studies performed on mouse skin have indicated that chemical carcinogenesis can be subdivided into two distinct stages, initiation and promotion. Initiation results from exposure to a classical mutagenic carcinogen and is irreversible even after a single exposure.
Stuart H. Yuspa +3 more
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Transformation of human cells by DNAs ineffective in transformation of NIH 3T3 cells. [PDF]
Proceedings of the National Academy of Sciences, 1985 Neonatal human foreskin fibroblasts can be transformed to anchorage-independent growth by transfection with DNAs inefficient in transforming NIH 3T3 cells. Human cells transfected with DNA from GM 1312, a multiple myeloma cell line, or MOLT-4, a permanent lymphoblast line, grow without anchorage at a much higher frequency than do the parental cells and
Paul T. Strickland +4 more
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Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion. [PDF]
, 2015 The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental
Bosco MC +10 more
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Taming the Digital Leviathan: Automated Decision-Making and International Human Rights
AJIL Unbound, 2020 Enthusiasm abounds about the potential of artificial intelligence to automate public decision-making. The rise of machine learning and computational text analysis together with the proliferation of digital platforms has raised the prospect of “robo ...
Malcolm Langford
doaj +1 more source
Life, 2023 The introduction of plasmids into Agrobacterium cells is one of the key steps in the Agrobacterium-mediated transformation of plants for gene editing applications.
Xiang Liu +6 more
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MiR-7 Promotes Epithelial Cell Transformation by Targeting the Tumor Suppressor KLF4
PLoS ONE, 2014 MicroRNAs (miRNAs) are endogenous small non-coding RNAs that have a pivotal role in the post-transcriptional regulation of gene expression and their misregulation is common in different types of cancer.
Karla F. Meza-Sosa +5 more
semanticscholar +1 more source
Frontiers in Physiology, 2014 Rapid development and deployment of engineered nanomaterials such as carbon nanotubes (CNTs) in various commercial and biomedical applications have raised concerns about their potential adverse health effects, especially their long-term effects which ...
Warangkana eLohcharoenkal +7 more
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OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation
Cell Death and Disease, 2014 Human cell transformation is a key step for oncogenic development, which involves multiple pathways; however, the mechanism remains unclear. To test our hypothesis whether cell oncogenic transformation shares some mechanisms with the process of ...
W. Ng +11 more
semanticscholar +1 more source
Notch and Schwann cell transformation [PDF]
Oncogene, 2004 Benign plexiform neurofibromas in NF1 patients can transform spontaneously into malignant peripheral nerve sheath tumors (MPNSTs). Although mutations in the p53 gene have been found in a subset of MPNSTs and mouse models support a role for p53 mutations in malignant conversion, we found that each of three Schwann cell lines derived from human MPNSTs ...
Peggy Wallace +9 more
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Cell Dynamics Simulation of Kolmogorov-Johnson-Mehl-Avrami Kinetics of Phase Transformation
, 2005 In this study, we use the cell dynamics method to test the validity of the Kormogorov-Johnson-Mehl-Avrami (KJMA) theory of phase transformation. This cell dynamics method is similar to the well-known phase-field model, but it is a more simple and ...
Iwamatsu, Masao, Nakamura, Masato
core +1 more source