Results 21 to 30 of about 2,227,755 (198)
4 open, 2019 The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
iScience, 2020 Summary: Cell-cycle quiescence is a common feature of early germline development in many animal species. In Drosophila germline progenitors (pole cells), both G2/M and G1/S transitions are blocked.
Shumpei Morita +3 more
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Visualizing cell state transition using Raman spectroscopy. [PDF]
PLoS ONE, 2014 System level understanding of the cell requires detailed description of the cell state, which is often characterized by the expression levels of proteins.
Taro Ichimura +6 more
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Molecular Therapy: Nucleic Acids, 2021 T cells exhibit heterogeneous functional states, which correlate with responsiveness to immune checkpoint blockade and prognosis of tumor patients. However, the molecular regulatory mechanisms underlying the dynamic process of T cell state transition ...
Min Yan +11 more
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Gold(III)-pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents [PDF]
, 2015 Transition metals offer many possibilities in developing potent chemotherapeutic agents. They are endowed with a variety of oxidation states, allowing for the selection of their coordination numbers and geometries via the choice of proper ligands ...
Brustolin, Leonardo +7 more
core +2 more sources
4 open, 2019 It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Control of cell state transitions
Nature, 2022 Understanding cell state transitions and purposefully controlling them is a longstanding challenge in biology. Here we present cell state transition assessment and regulation (cSTAR), an approach for mapping cell states, modelling transitions between them and predicting targeted interventions to convert cell fate decisions.
Oleksii S. Rukhlenko +11 more
openaire +3 more sources
Plasticity of cancer cell invasion: Patterns and mechanisms
Translational Oncology, 2021 Cancer cell migration and invasion are integral components of metastatic disease, which is the major cause of death in cancer patients. Cancer cells can disseminate and migrate via several alternative mechanisms including amoeboid cell migration ...
Jia-shun Wu +5 more
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Collective motion and nonequilibrium cluster formation in colonies of gliding bacteria [PDF]
, 2012 We characterize cell motion in experiments and show that the transition to collective motion in colonies of gliding bacterial cells confined to a monolayer appears through the organization of cells into larger moving clusters.
Bar, Markus +5 more
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A self-driven phase transition drives Myxococcus xanthus fruiting body formation [PDF]
, 2019 Combining high-resolution single cell tracking experiments with numerical simulations, we show that starvation-induced fruiting body (FB) formation in Myxococcus xanthus is a phase separation driven by cells that tune their motility over time.
Bahar, Fatmagul +7 more
core +2 more sources