Results 31 to 40 of about 9,650,343 (306)

Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition

open access: yesMolecular Therapy: Nucleic Acids, 2021
T cells exhibit heterogeneous functional states, which correlate with responsiveness to immune checkpoint blockade and prognosis of tumor patients. However, the molecular regulatory mechanisms underlying the dynamic process of T cell state transition ...
Min Yan   +11 more
doaj   +1 more source

A cellular hierarchy of Notch and Kras signaling controls cell fate specification in the developing mouse salivary gland

open access: yes, 2023
The development of the mouse salivary gland involves a tip-driven process of branching morphogenesis that takes place in concert with differentiation into acinar, myoepithelial, and ductal (basal and luminal) sub -line-ages.
Bonkyoung Koo   +15 more
core   +1 more source

Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli

open access: yes, 2019
Many fungal species are dimorphic, exhibiting both unicellular yeast-like and filamentous forms. Schizosaccharomyces japonicus, a member of the fission yeast clade, is one such dimorphic fungus.
Martin, Sophie G.   +3 more
core   +2 more sources

The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback [PDF]

open access: yes, 2009
The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we apply
Brazma Alvis   +30 more
core   +1 more source

Transition state characteristics during cell differentiation.

open access: yesPLoS Computational Biology, 2018
Models describing the process of stem-cell differentiation are plentiful, and may offer insights into the underlying mechanisms and experimentally observed behaviour.
Rowan D Brackston   +2 more
doaj   +1 more source

MYB64 and MYB119 are required for cellularization and differentiation during female gametogenesis in Arabidopsis thaliana. [PDF]

open access: yesPLoS Genetics, 2013
In angiosperms, the egg cell forms within the multicellular, haploid female gametophyte. Female gametophyte and egg cell development occurs through a unique process in which a haploid spore initially undergoes several rounds of synchronous nuclear ...
David S Rabiger, Gary N Drews
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo   +9 more
wiley   +1 more source

Cell approach to glass transition

open access: yesJournal of Physics: Condensed Matter, 2003
We present a novel theoretical approach to understanding the complex dynamics of glass-forming liquids, granular packings and amorphous solids. This theory, which is an elaboration of the free volume and inherent structure approaches, allows one to retrieve the thermodynamical properties of these systems from studies of geometrical and topological ...
Aste, Tomaso, Coniglio, A
openaire   +4 more sources

Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine [PDF]

open access: yes, 2010
Coordination between cell fate specification and cell cycle control in multicellular organisms is essential to regulate cell numbers in tissues and organs during development, and its failure may lead to oncogenesis.
Segref, Alexandra   +9 more
core   +1 more source

Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines. [PDF]

open access: yesPLoS ONE, 2016
BACKGROUND:Epithelial to mesenchymal transition is a process in which a cell experiences a loss of epithelial cell characteristics and acquires a more mesenchymal cell phenotype.
Elizabeth J Sandquist   +6 more
doaj   +1 more source

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