Results 21 to 30 of about 9,650,343 (306)

Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells [PDF]

, 2003
In view of the common regulatory mechanism that induces transcription of tie mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit.
Patric Turowski, Franckhauser, Céline, Ned J. C. Lamb, Lamb, Ned,, Celine Franckhauser, Fernandez, A, Lamb, NJC, Turowski, P, Fernandez, Anne, Turowski, Patric, Morris, May, Franckhauser, C, Vaglio, P, Vaglio, Philippe, Morris, MC, Lamb, Ned, J., Anne Fernandez, May C. Morris, Anne Fern, Philippe Vaglio   +19 more
core   +1 more source

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress

4 open, 2019
The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer [PDF]

, 2011
The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility.
Richard R. Meehan, Caldwell Helen, Dubois-Marshall, Sylvie, Sylvie Dubois-Marshall, Helen Caldwell, Sims, Andrew H., Sims Andrew H., Elad Katz, Katz Elad, Elad Katz, Meehan Richard R., Meehan, Richard R, Richard R Meehan, Gautier Philippe, David J. Harrison, Richard R, Harrison David J., Gautier, Philippe, Dubois-Marshall Sylvie, Sims, Andrew H, Philippe Gautier, Harrison, David J, David J Harrison, Katz, Elad, Andrew H. Sims, Meehan, Richard R., Andrew H Sims, Caldwell, Helen, Harrison, David J., Harrison, David J.; id_orcid   +29 more
core   +1 more source

Eicosanoids in carcinogenesis

4 open, 2019
Inflammation is the body's reaction to pathogenic (biological or chemical) stimuli and covers a burgeoning list of compounds and pathways that act in concert to maintain the health of the organism.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Visualizing cell state transition using Raman spectroscopy. [PDF]

PLoS ONE, 2014
System level understanding of the cell requires detailed description of the cell state, which is often characterized by the expression levels of proteins.
Taro Ichimura, Liang-da Chiu, Katsumasa Fujita, Satoshi Kawata, Tomonobu M Watanabe, Toshio Yanagida, Hideaki Fujita   +6 more
doaj   +1 more source

Canine Transitional Cell Carcinoma [PDF]

Journal of Veterinary Internal Medicine, 2003
Abstract Transitional cell carcinoma (TCC) of the urinary bladder, the most common malignancy of the urinary tract in dogs, is challenging to both diagnose and treat effectively. The prevalence of this disease may be increasing. The etiology of canine TCC is likely multifactorial.
Anthony J, Mutsaers, William R, Widmer, Deborah W, Knapp   +2 more
openaire   +2 more sources

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Repression of G1/S Transition by Transient Inhibition of miR-10404 Expression in Drosophila Primordial Germ Cells

iScience, 2020
Summary: Cell-cycle quiescence is a common feature of early germline development in many animal species. In Drosophila germline progenitors (pole cells), both G2/M and G1/S transitions are blocked.
Shumpei Morita, Ryoma Ota, Makoto Hayashi, Satoru Kobayashi   +3 more
doaj   +1 more source

Plasticity of cancer cell invasion: Patterns and mechanisms

Translational Oncology, 2021
Cancer cell migration and invasion are integral components of metastatic disease, which is the major cause of death in cancer patients. Cancer cells can disseminate and migrate via several alternative mechanisms including amoeboid cell migration ...
Jia-shun Wu, Jian Jiang, Bing-jun Chen, Ke Wang, Ya-ling Tang, Xin-hua Liang   +5 more
doaj   +1 more source