Results 41 to 50 of about 9,650,343 (306)

Epithelial-to-mesenchymal transition proceeds through directional destabilization of multidimensional attractor

eLife, 2022
How a cell changes from one stable phenotype to another one is a fundamental problem in developmental and cell biology. Mathematically, a stable phenotype corresponds to a stable attractor in a generally multi-dimensional state space, which needs to be ...
Weikang Wang, Dante Poe, Yaxuan Yang, Thomas Hyatt, Jianhua Xing   +4 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Snail and Slug Promote Epithelial-Mesenchymal Transition through β-Catenin–T-Cell Factor-4-dependent Expression of Transforming Growth Factor-β3

, 2019
Members of the Snail family of transcription factors have been shown to induce epithelial-mesenchymal transition (EMT), a fundamental mechanism of embryogenesis and progressive disease.
Hay, Elizabeth D., Olsen, Bjorn R., Medici, Damian   +2 more
core   +1 more source

Injury activates transient olfactory stem cell states with diverse lineage capacities [PDF]

, 2017
Tissue homeostasis and regeneration are mediated by programs of adult stem cell renewal and differentiation. However, the mechanisms that regulate stem cell fates under such widely varying conditions are not fully understood. Using single-cell techniques,
Sanchez, Michael A, Ngai, John, Nir Yosef, Yoon Gi Choi, Gadye, Levi, Purdom, Elizabeth, Wagner, Allon, Choi, Yoon Gi, Risso, Davide, Michael B. Cole, Levi Gadye, Ariane Baudhuin, Fletcher, Russell B, Davide Risso, Street, Kelly, John Ngai, Michael A. Sanchez, Diya Das, Yosef, Nir, Dudoit, Sandrine, Baudhuin, Ariane, Sandrine Dudoit, Das, Diya, Kelly Street, Elizabeth Purdom, Cole, Michael B, Russell B. Fletcher, Allon Wagner   +27 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Distributing Power : a Transition to a Civic Energy Future [PDF]

, 2015
The overarching challenge for UK energy policy is to ensure the delivery of secure, affordable energy in a way that meets the emission reductions targets laid out in the Climate Change Act (2008).
Realising Transition Pathways Engine Room, Emanuel-Yusuf, Damie, Robertson, Elizabeth, Hall, Stephan, Longhurst, Noel, Barton, John, O’Grady, Áine, Robinson, Elaine, Sherry-Brennan, Fionnguala, Johnson, Victoria   +9 more
core  

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Jamming state transition and collective cell migration

Journal of Biological Engineering, 2019
Jamming state transition has been used in literature to describe migrating-to-resting cell state transition during collective cell migration without proper rheological confirmation.
Ivana Pajic-Lijakovic, Milan Milivojevic
doaj   +1 more source

Gintonin Isolated from Ginseng Inhibits the Epithelial—Mesenchymal Transition Induced by TGF-β in A549 Lung Cancer Cells

Plants, 2023
Epithelial-to-mesenchymal transition (EM transition) is a process wherein epithelial cells lose their intrinsic characteristics and cell–cell junctions and differentiate into a mesenchymal phenotype.
Sung Jin Kim, Seung-Yeol Nah, Il-Ho Park, Myoung-Sook Shin, Ki Sung Kang   +4 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source