Results 61 to 70 of about 9,650,343 (306)

Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures

Nature Communications, 2022
Cell fate dynamics during human naïve pluripotency establishment remain poorly understood. Here, Bi et al. depict a high-resolution cell roadmap of the primed-to-naïve pluripotency transition, providing hints for embryo modeling-related studies.
Yan Bi, Zhifen Tu, Jianfeng Zhou, Xuehao Zhu, Hong Wang, Shaorong Gao, Yixuan Wang   +6 more
doaj   +1 more source

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source

Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells

, 2019
Totipotency refers to the ability of a cell to generate all the cell types of an organism. Unlike pluripotency, the establishment of totipotency is poorly understood.
Djekidel, Mohamed Nadhir, Fu, Xudong, Wu, Xiaoji, Zhang, Yi, Mohamed Nadhir Djekidel, Xudong Fu, Yi Zhang, Xiaoji Wu   +7 more
core   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Epithelial mesenchymal transition and cancer stem cell markers in oral epithelial dysplasia and oral squamous cell carcinoma

Polish Journal of Pathology
The role of cancer stem cells (CSC) in oral cancer is widely accepted. Yet, the existence of CSC in dysplastic tissue and the molecular pathways of progression from dysplasia to malignancy remain to be explored.
Burcu Tokozlu, Özlem Özer Yücel, Sibel E. Gültekin, Leyla Arslan Bozdağ   +3 more
doaj   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Slug-based epithelial-mesenchymal transition gene signature is associated with prolonged time to recurrence in glioblastoma [PDF]

, 2011
Background We previously identified a precise stage-associated gene expression signature of coordinately expressed genes, including the transcription factor Slug (SNAI2) and other epithelial mesenchymal transition (EMT) markers, present in ...
Jessica J. Kandel, Peter Canoll, Darrell J. Yamashiro, Wei-Yi Cheng, Dimitris Anastassiou   +4 more
core  

Cdc42-mediated tubulogenesis controls cell specification. [PDF]

, 2009
SummaryUnderstanding how cells polarize and coordinate tubulogenesis during organ formation is a central question in biology. Tubulogenesis often coincides with cell-lineage specification during organ development. Hence, an elementary question is whether
Greiner, Thomas, Johansson, Jenny, Semb, Tor Henrik, Wolfhagen Sand, Fredrik,, Greiner, Thomas Uwe, Kesavan, Gokul,, Brakebusch, Cord, Greiner, Thomas,, Sand, Fredrik Wolfhagen, Johansson, Jenny,, Johansson, Jenny Kristina, Kobberup, Sune, Wolfhagen Sand, Fredrik, Kobberup, Sune,, Wu, Xunwei, Semb, Henrik, Semb, Henrik,, Lund University., Kesavan, Gokul   +18 more
core   +1 more source

Inference of Cell Fate Transition from Single-Cell Transcriptomic Data [PDF]

, 2022
Rapid growth of single-cell technologies provides unprecedented opportunities for close scrutinizing of heterogeneous cell states. However, detecting cell fate transition especially inferring the intermediate cell states (ICS) and transition cells from ...
sha, yutong
core   +1 more source

The regulatory network for the G1/S transition in Saccharomyces cerevisiae promotes the understanding of cancer developmental mechanisms

Biotechnology & Biotechnological Equipment
The G1/S transition is crucial for regulating the initiation of cell division and is highly conserved across eukaryotes. This phase of the cell cycle involves intricate transcriptional controls that are essential for understanding cell proliferation ...
Cheng Zhou, Pan Li, Yuwei Qu, Jiahe Zuo, Zhimin Hao, Tongtong Liu   +5 more
doaj   +1 more source