Results 1 to 10 of about 182,626 (156)

Precancerous niche (PCN), a product of fibrosis with remodeling by incessant chronic inflammation [PDF]

4open, 2019
Fibroblasts are actively involved in the creation of the stroma and the extracellular matrix which are important for cell adhesion, cell–cell communication, and tissue metabolism.

exaly   +5 more sources

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress [PDF]

4open, 2019
The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...

exaly   +5 more sources

Precancerous niche remodelling dictates nascent tumour persistence. [PDF]

Nature
Abstract Interactions between mutant cells and their environment have a key role in determining cancer susceptibility 1–3 . However, understanding of how the precancerous microenvironment contributes to early tumorigenesis remains limited.
Bartomeu Colom, Steffen Rulands, Mirko H H Schmidt   +2 more
exaly   +9 more sources

Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: Mechanisms and clinical implications

Frontiers in Immunology, 2022
The majority of colorectal cancers (CRCs) are thought to arise from precancerous adenomas. Upon exposure to diverse microenvironmental factors, precancerous stem cells (pCSCs) undergo complex genetic/molecular changes and gradually progress to form ...
Guanglin Cui, Zhigang Pang
exaly   +6 more sources

Human Lingual Biofilm Signatures in Gastrointestinal Disease: A Scoping Review [PDF]

International Dental Journal
: Introduction and aims: The tongue dorsum represents a structurally complex oral biofilm niche that has traditionally been regarded as indicative of systemic health.
Kausar Sadia Fakhruddin, Moyad Shahwan, Ayaana Kamal, Osman Elmobarik, Thitaya Chaiboonyarak, Alexander Patera Nugraha, Han-Sung Jung, Lakshman Samaranayake, Thantrira Porntaveetus   +8 more
doaj   +2 more sources

Heterogeneous mechanisms, risk stratification, and translational advances in the malignant transformation of oral potentially malignant disorders to oral squamous cell carcinoma [PDF]

Frontiers in Molecular Biosciences
Oral potentially malignant disorders (OPMDs) represent important precursor conditions in the development of oral squamous cell carcinoma (OSCC) and provide a critical window for early prevention, risk assessment, and precision intervention of oral cancer.
Zijing Yu, Zijing Yu, Hutao Peng, Hutao Peng, Xiaobo Cheng, Xiaobo Cheng, Wenpin Xu, Wenpin Xu, Yupei Wang, Yupei Wang, Yinhu Xiao, Yinhu Xiao, Ting Wei, Ting Wei, Zhizhen Huang, Zhizhen Huang, Yang He, Yang He, Jian Wang, Jian Wang   +19 more
doaj   +2 more sources

Spatiotemporal multi-omics analysis uncovers NAD-dependent immunosuppressive niche triggering early gastric cancer [PDF]

Signal Transduction and Targeted Therapy
Understanding the cellular origins and early evolutionary dynamics that drive the initiation of carcinogenesis is critical to advancing early detection and prevention strategies.
Pingting Gao, Chunman Zuo, Wei Yuan, Jiabin Cai, Xiaoqiang Chai, Ruijie Gong, Jia Yu, Lu Yao, Wei Su, Zuqiang Liu, Shengli Lin, Yun Wang, Mingyan Cai, Lili Ma, Quanlin Li, Pinghong Zhou   +15 more
doaj   +2 more sources

Undervalued ubiquitous proteins

4 open, 2019
The role of ubiquitous proteins (UPs) and their corresponding enzymes have been underestimated in carcinogenesis as the focus of much research revolved around measuring mutations and/or other genetic epiphenomena as surrogate markers of cancer and cancer
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Expression of Stemness Markers in the Cervical Smear of Patients with Cervical Insufficiency

Cells, 2023
The presence of stem cells has been previously described in human precancerous and malignant cervical cultures. Previous studies have shown a direct interplay of the stem cell niche, which is present in practically every tissue with the extracellular ...
Savvia Pittokopitou, Despina Mavrogianni, Vasilios Pergialiotis, Kalliopi I. Pappa, Panagiotis Antsaklis, Marianna Theodora, Michail Sindos, Angeliki Papapanagiotou, Aikaterini Domali, Sofoklis Stavros, Peter Drakakis, George Daskalakis   +11 more
doaj   +1 more source

Microbiome and morbid obesity increase pathogenic stimulus diversity

4 open, 2019
The microbiome, the relationship between environmental factors, a high-fat diet, morbid obesity, and host response have been associated with cancer, only a small fraction of which (
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source