Results 11 to 20 of about 182,626 (156)

Spatiotemporal transcriptomics for tumour microenvironment remodelling in cancer progression and therapy. [PDF]

Clin Transl Med
This review summarises how spatial transcriptomics technologies reveal tumour microenvironment heterogeneity and support the inference of dynamic remodelling during cancer progression. Abstract Background Spatiotemporal transcriptomics (STT) integrates spatially resolved gene expression with temporal information derived from staged samples, paired ...
Kang Y, Wang Q, Xu S, Guo J, Ming Y, Chen W, Wang M, Huang Z, Huang Y, Jia B.   +9 more
europepmc   +2 more sources

An introduction to niche construction theory [PDF]

, 2016
Niche construction refers to the modification of selective environments by organisms. Theoretical and empirical studies of niche construction are increasing in importance as foci in evolutionary ecology.
Matthews, Blake, Laland, Kevin Neville, Blake Matthews, Marcus W. Feldman, Kevin Laland, Feldman, Marcus W., Laland K, Matthews B, Feldman, Marcus W. (author), Feldman MW, Laland, Kevin (author), Matthews, Blake (author), Laland, Kevin Neville; id_orcid   +12 more
core   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Inflammatory cytokines and a diverse cervicovaginal microbiota associate with cervical dysplasia in a cohort of Hispanics living in Puerto Rico.

PLoS ONE, 2023
Cervical cancer (CC) is women's fourth most common cancer worldwide. A worrying increase in CC rates in Hispanics suggests that besides Human papillomavirus infections, there may be other cofactors included in the epithelial microenvironment that could ...
Eduardo Tosado-Rodríguez, Loyda B Mendez, Ana M Espino, Stephanie Dorta-Estremera, Edna E Aquino, Josefina Romaguera, Filipa Godoy-Vitorino   +6 more
doaj   +1 more source

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

The niche construction perspective : a critical appraisal [PDF]

, 2014
For financial support, the authors thank Biotechnology and Biological Sciences Research Council, The Economic and Social Research Council, The Natural Environment Research Council, the Leverhulme Trust, the European Research Council, and the Royal ...
Laland, Kevin N., Scott-Phillips, Thomas C., Dickins, T.E., Shuker, D.M., West, S.A., Dickins, Thomas E., West, Stuart A., Scott-Phillips, T.C., Laland, K.N., Shuker, David M., Shuker, D., West, S., Dickins, T., Laland, K., Scott-Phillips, T., Laland, Kevin N.; id_orcid   +15 more
core   +1 more source

Prelude and premise to the special issue: disruption of homeostasis-induced signaling and crosstalk in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The vast majority of anticancer strategies are symptomatic but in order to achieve some tangible progress, we need to identify the cause(s) of the majority of cancers.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Eicosanoids in carcinogenesis

4 open, 2019
Inflammation is the body's reaction to pathogenic (biological or chemical) stimuli and covers a burgeoning list of compounds and pathways that act in concert to maintain the health of the organism.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell-State Plasticity in the CFTR Modulator Era. [PDF]

Cell Prolif
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Umashankar B, Pankonien I, Amaral M, Ooi CY, Jardé T, Waters SA.   +5 more
europepmc   +2 more sources