Results 31 to 40 of about 182,626 (156)

Determining trophic niche width: a novel approach using stable isotope analysis [PDF]

, 2004
1. Although conceptually robust, it has proven difficult to find practical measures of niche width that are simple to obtain, yet provide an adequate descriptor of the ecological position of the population examined. 2.
Bearhop, S., Bearhop, Stuart, Fuller, R.A., Waldron, S., Adams, C.E., Macleod, H., Fuller, Richard A., Adams, Colin E., Waldron, Susan   +8 more
core   +1 more source

NF-κB signaling and crosstalk during carcinogenesis

4 open, 2019
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M., Lang Florian, Jamall Ijaz S.   +2 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

An oncogenic KRAS-driven secretome involving TNFα promotes niche preparation prior to pancreatic cancer onset

Molecular Cancer
Background Pancreatic ductal adenocarcinomas (PDACs) are highly lethal and aggressive with oncogenic KRAS being the main oncogenic driver of the disease.
Chantal Allgöwer, Medhanie A. Mulaw, James Nagai, Sandra Wiedenmann, Elena Anne Ringel, Benedetta Ferrara, Lorenzo Piemonti, Tengku Ibrahim Maulana, Luisa T. Ferreira, Adam Flinders, Claudia Teufel, Leon Reichardt, Paul B. Lopatta, Dharini Srinivasan, Anton Lahusen, Thomas Seufferlein, Nadine Therese Gaisa, Annika Beck, Jessica Lindenmayer, Michael K. Melzer, Eleni Zimmer, Elodie Roger, Sandra Heller, J.-Mathias Löhr, Stefan Liebau, Peter Loskill, Yuan-Na Lin, Paolo Riccardo Camisa, Claus Jorgensen, Stefano Crippa, Matthias Meier, Meike Hohwieler, Ivan G. Costa, Markus Breunig, Alexander Kleger   +34 more
doaj   +1 more source

Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation.

PLoS Computational Biology, 2019
Clonal hematopoiesis of indeterminate potential (CHIP) is a recently identified process where older patients accumulate distinct subclones defined by recurring somatic mutations in hematopoietic stem cells.
Derek S Park, Afua A Akuffo, David E Muench, H Leighton Grimes, Pearlie K Epling-Burnette, Philip K Maini, Alexander R A Anderson, Michael B Bonsall   +7 more
doaj   +1 more source

Predicting Oral Cancer From Precursor Lesions: The Case for a Standardized Framework of Analysis to Improve Prediction Modeling

Head &Neck, EarlyView.
ABSTRACT Oral Cancer often occurs from the transformation of precursor lesions, and this offers an opportunity for early detection. Current methods to assess risk of precursor lesion progression to oral cancer incompletely predict risk. A multimodal framework that leverages machine learning is needed to improve prediction.
Michael E. Troka, James C. Gates
wiley   +1 more source

gerardommc/Niche-centroids: Final

, 2022
Final version of the analyses of the paper: Gerardo Martín, Carlos Yáñez-Arenas & Xavier Chiappa-Carrara (2022). Discrepancies between point process models and environmental envelopes identify the niche centroid – geography configuration.
g3rard0ip
core   +2 more sources

Somatic Mutation Theory - Why it's Wrong for Most Cancers

Cellular Physiology and Biochemistry, 2016
Hysteron proteron reverses both temporal and logical order and this syllogism occurs in carcinogenesis and the somatic mutation theory (SMT): the first (somatic mutation) occurs only after the second (onset of cancer) and, therefore, observed somatic ...
Björn L.D.M. Brücher, Ijaz S. Jamall
doaj   +1 more source

Oral and Fecal Microbial Dysbiosis as Non‐Invasive Diagnostic Biomarkers for Gastrointestinal Cancers: A Systematic Review and Meta‐Analysis of Diagnostic Accuracy

International Journal of Cancer, EarlyView.
ABSTRACT Gastrointestinal (GI) cancers, including esophageal (EC), gastric (GC), and colorectal cancer (CRC), impose a substantial global burden, with early detection remaining crucial for improving patient outcomes. The oral and gut microbiota are increasingly implicated in cancer development and hold promise as sources of non‐invasive biomarkers ...
Saidi Hu, Zhouyan Chen, Yanxia Li, Qingyan Liao, Mingdong Luo, Danyang Song, Hanyue Yu, Yuetong Gao, Shuanglong Yang, Siran Wan, Shunhong Zhang, Chenchen Luo, Lin‐Yong Zhao   +12 more
wiley   +1 more source