Results 51 to 60 of about 182,626 (156)

The evolution of NICHE: assessing the challenges and opportunities for a community health organisation in Cork city [PDF]

, 2020
This study was proposed by NICHE, a community health organisation based on the North side of Cork City. NICHE wanted to capture and reflect on the role that it has played in that community for the last 20 years.
Canty, Catherine Majella
core   +1 more source

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

The FEBS Journal, EarlyView.
Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa, Meng‐Lay Lin, Stuart A. C. McDonald   +2 more
wiley   +1 more source

Refining the Correa cascade: Gastric stem cell plasticity, niche remodelling, and parallel pathways to neoplasia

Pharmacological Research
Gastric cancer remains a leading cause of cancer mortality. The Correa cascade—stepwise progression from inflammation through atrophic gastritis, metaplasia and dysplasia to adenocarcinoma—has long defined its pathogenesis.
Tai Zhang, Zheng Wang, Beihua Zhang, Xudong Tang   +3 more
doaj   +1 more source

Metaplasia and the Origins of Gastric Cancer—Implications for Screening and Surveillance

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Gastric intestinal metaplasia (IM) is a key step in the development of intestinal‐type gastric cancer (GC) and a checkpoint for preventive strategies. The risk of progression to GC is highest for incomplete IM and extensive severe IM as classified by scoring systems such as operative link on gastric intestinal metaplasia (OLGIM) assessment ...
Khay Guan Yeoh
wiley   +1 more source

PRECANCEROUS CERVICAL LESIONS [PDF]

, 2016
Treatment approach Neoplastic epithelial changes (cervical intraepithelial neoplasia, CIN) can be precancerous.
P. R. Abakarova, E. A. Mezhevitinova, Y. S. Khlebkova   +2 more
core   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

Liquid Biopsy: Past, Present, and Future

MedComm, Volume 7, Issue 11, November 2026.
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Jiachen Liu, Dianjie Zeng, Keran Zhao, Yuxi Wang, Huijie Hu, Fei Deng, Yinhuai Wang, Liya Sun, Liangmin Fu   +8 more
wiley   +1 more source

Modulation of adipose-derived stem cell behavior by prostate pathology-associated plasma: insights from in vitro exposure

Scientific Reports
Adipose-derived stem cells (ADSCs) are promising in regenerative medicine. Their proliferation, survival and activation are influenced by specific signals within their microenvironment, also known as niche.
Sara Cruciani, Donatella Coradduzza, Francesca Balzano, Giuseppe Garroni, Emanuela Azara, Renzo Pala, Alessandro P. Delitala, Massimo Madonia, Alessandro Tedde, Giampiero Capobianco, Marco Petrillo, Cecilia Angelucci, Ciriaco Carru, Carlo Ventura, Margherita Maioli   +14 more
doaj   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, Volume 2, Issue 4, October 2026.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source