Results 261 to 270 of about 15,438,001 (312)

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Strenuous training combined with erythropoietin induces red cell volume expansion-mediated hypervolemia and alters systemic and skeletal muscle iron homeostasis.

Am J Physiol Regul Integr Comp Physiol
Ryan BJ, Barney DE, McNiff JL, Drummer DJ, Howard EE, Gwin JA, Carrigan CT, Murphy NE, Wilson MA, Pasiakos SM, McClung JP, Margolis LM.   +11 more
europepmc   +1 more source

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Studying cell volume beyond cell volume

2021
The first part of the paper describes two simple microscopic techniques that we use in our laboratory. One measures cell volumes in adherent cultures and the other measures cell dry mass; both measurements are done on the same instrument (a standard bright-field transmission microscope with only one or two narrow-band color filters added) and on the ...
openaire   +2 more sources

The cytoskeleton and cell volume regulation

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2001
Although the precise mechanisms have yet to be elucidated, early events in osmotic signal transduction may involve the clustering of cell surface receptors, initiating downstream signaling events such as assembly of focal adhesion complexes, and activation of, e.g.
Pedersen, Stine F., Hoffmann, Else Kay, Mills, J.W.   +2 more
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Cell Volume Regulation in the Nephron

Annual Review of Physiology, 1990
Nearly every cell in the kidney can volume regulate in response to a hypertonic challenge. Some are able to respond immediately to hyperosmotic media by a RVI. Other cells require stimulation prior to exposure to hyperosmolarity to demonstrate RVI. An increase of intracellular osmolytes during RVI usually occurs by an increase of NaCl influx either via
C, Montrose-Rafizadeh, W B, Guggino
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Cell Volume Regulatory Mechanisms

2006
Prerequisites for cell survival include avoidance of excessive alterations of cell volume. Cells counterbalance the osmolarity due to cellular accumulation of organic substances by uneven distribution of inorganic ions. They extrude Na(+) in exchange for K(+) by the Na(+) /K(+) ATPase. The cell membrane is less permeable to Na(+) than to K(+) . The K(+)
B, Friedrich, I, Matskevich, F, Lang
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Regulation of cell volume by glycosaminoglycans

Journal of Cellular Biochemistry, 2011
AbstractCell volume is regulated by a delicate balance between ion distribution across the plasma membrane and the osmotic properties of intra‐ and extracellular components. Using a fluorescent calcein indicator, we analysed the effects of glycosaminoglycans on the cell volume of hyaluronan producing fibroblasts and hyaluronan deficient HEK cells over ...
Jelena, Joerges, Tobias, Schulz, Jeannine, Wegner, Udo, Schumacher, Peter, Prehm   +4 more
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Cell volume and hepatocellular function

Journal of Hepatology, 1995
The hepatocellular hydration state, i.e. liver cell volume, is a dynamic parameter, which changes within minutes in response to alterations in the environmental or hormonal milieu. These changes in cell hydration act as a signal which modifies metabolism and gene expression due to complex alterations in protein phosphorylation.
D, Häussinger, F, Schliess
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