Results 81 to 90 of about 2,209,887 (300)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Impact of Local versus Global Ligand Density on Cellular Adhesion

, 2011
α(v)β(3) integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments ...
Janosch A. Deeg, Ilia Louban, Aydin, D., Deeg, J., Daniel Aydin, Joachim P. Spatz, Kessler, H., Spatz, J., Louban, I., Christine Selhuber-Unkel, Selhuber-Unkel, C., Horst Kessler   +11 more
core   +1 more source

Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair [PDF]

, 2012
The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment.
Susan McIntyre, Mcintyre, Susan, Mark Marsden, Rehab AlJamal-Naylor, Fiona Rossi, Harrison, Beth, Marsden, Mark, Linda Wilson, Aljamal-naylor, Rehab, Wilson, Linda, David J. Harrison, Beth Harrison, Rossi, Fiona, Harrison, David J., Harrison, David J.; id_orcid   +14 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Impact of Local versus Global Ligand Density on Cellular Adhesion

, 2016
αvβ3 integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with
Horst Kessler (71356), Janosch A. Deeg (2210782), Christine Selhuber-Unkel (204030), Daniel Aydin (172271), Ilia Louban (2175242), Joachim P. Spatz (112990)   +5 more
core   +1 more source

Measuring cell adhesion forces with the atomic force microscope at the molecular level [PDF]

, 2002
In the past 25 years many techniques have been developed to characterize cell adhesion and to quantify adhesion forces. Atomic force microscopy (AFM) has been used to measure forces in the pico-newton range, an experimental technique known as force ...
Benoit, M., Gaub, H. E.
core   +1 more source

Investigating changes in cellular adhesion induced by electrostatically spun tissue engineering scaffolds

, 2006
Paper investifates changes in cellular adhesion induced by electrostatically spun tissue engineering ...
Andrews, K.D., Black, R.A., Hunt, J.A.
core   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation [PDF]

, 2011
The ability of tendons to glide smoothly during muscle contraction is impaired after injury by fibrous adhesions that form between the damaged tendon surface and surrounding tissues. To understand how adhesions form we incubated excised tendons in fibrin
Al-Youha Sarah, Susan H Taylor, Van Agtmael Tom, Van Agtmael, T., Wong, J., Lu Yinhui, Wong Jason, Kadler Karl E., Duncan A. McGrouther, Jason Wong, Taylor, Susan H, Kadler, Karl E; id_orcid, Al-Youha, Sarah, McGrouther, Duncan A, Agarwal, S., Duncan A McGrouther, Karl E Kadler, McGrouther Duncan A., Lu, Y., Yinhui Lu, Karl E. Kadler, Al-Youha, S., Sarah Al-Youha, Taylor Susan H., Kadler, K.E., Lu, Yinhui, Tom Van Agtmael, Taylor, S.H., McGrouther, D.A., Susan H. Taylor, Van Agtmael, Tom, Wong, Jason; id_orcid, Wong J., Al-Youha S., van Agtmael T., McGrouther D.A., Taylor S.H., Lu Y., Kadler K.E.   +38 more
core   +2 more sources

Morphofunctional characteristics of endothelial cells in coronary atherosclerosis [PDF]

Archives of Biological Sciences, 2011
Atherosclerosis represents a complex disease which encompasses all the components of the vascular wall. Nevertheless, according to all known theories of the pathogenesis of atherosclerosis, the key role in this process belongs to the endothelial cells,
Lačković Vesna, Tanasković Irena, Radak Đ., Nešić Vesna, Gluvić Z., Lačković Milena, Ašanin B., Radović S., Stanković Vesna, Đurić J., Nešić Jelena, Kanjuh V.   +11 more
doaj   +1 more source