Results 91 to 100 of about 2,209,887 (300)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Outer Membrane Protein YadA of Enteropathogenic Yersiniae Mediates Specific Binding to Cellular but Not Plasma Fibronectin [PDF]

, 1993
The binding of bacteria or bacterial products to host proteins of tissue extracellular matrix may be a mechanism of tissue adherence. We investigated interactions of the plasmid-encoded outer membrane protein YadA, which confers pathogenic functions on ...
Emmerich, F., Burkhardt, H., Kirsch, T., Schulze-Koops, Hendrik, Swoboda, B., Bull, C., Goodman, S., Heesemann, Jürgen   +7 more
core   +1 more source

Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy. [PDF]

PLoS ONE, 2015
Dissemination of prostate cancer (PCa) cells to the bone marrow is an early event in the disease process. In some patients, disseminated tumor cells (DTC) proliferate to form active metastases after a prolonged period of undetectable disease known as ...
Nazanin Ruppender, Sandy Larson, Bryce Lakely, Lori Kollath, Lisha Brown, Ilsa Coleman, Roger Coleman, Holly Nguyen, Peter S Nelson, Eva Corey, Linda A Snyder, Robert L Vessella, Colm Morrissey, Hung-Ming Lam   +13 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Shedding of APP limits its synaptogenic activity and cell adhesion properties

Frontiers in Cellular Neuroscience, 2014
The Amyloid precursor protein (APP) plays a central role in Alzheimer’s disease (AD) and has essential synapse promoting functions. Synaptogenic activity as well as cell adhesion properties of APP presumably depend on trans-cellular dimerization via its ...
Ronny eStahl, Ronny eStahl, Sandra eSchilling, Peter eSoba, Carsten eRupp, Tobias eHartmann, Katja eWagner, Gunter eMerdes, Simone eEggert, Stefan eKins   +9 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Receptors of cell adhesion and cellular recognition /

, 1996
Volume 3 of Biomembranes covers receptors of cell adhesion and cellular recognition. Proteins in the plasma membrane of cells are heavily involved in processes of cell adhesion, but such proteins were not actually isolated and characterized until the mid-
Lee, A. G.
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling

, 2023
Cell adhesion molecules, including integrins, cadherins, and claudins (CLDNs), are known to activate Src-family kinases (SFKs) that organize a variety of physiological and pathological processes; however, the underlying molecular basis remains unclear ...
Naoki Ichikawa-Tomikawa, Kotaro Sugimoto, Korehito Kashiwagi, Hideki Chiba   +3 more
core   +1 more source

Glycocalyx regulates the strength and kinetics of cancer cell adhesion revealed by biophysical models based on high resolution label-free optical data

Scientific Reports, 2020
The glycocalyx is thought to perform a potent, but not yet defined function in cellular adhesion and signaling. Since 95% of cancer cells have altered glycocalyx structure, this role can be especially important in cancer development and metastasis.
Nicolett Kanyo, Kinga Dora Kovacs, Andras Saftics, Inna Szekacs, Beatrix Peter, Ana R. Santa-Maria, Fruzsina R. Walter, András Dér, Mária A. Deli, Robert Horvath   +9 more
doaj   +1 more source