Results 111 to 120 of about 121,160 (299)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Self-organized spatial targeting of contractile actomyosin rings for synthetic cell division
Nature CommunicationsA key challenge for bottom-up synthetic biology is engineering a minimal module for self-division of synthetic cells. Actin-based cytokinetic rings are considered a promising structure to produce the forces required for the controlled excision of cell ...
María Reverte-López +5 more
doaj +1 more source
Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly
eLife, 2018 The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) proteins are critical for cellular membrane scission processes with topologies inverted relative to clathrin-mediated endocytosis.
Daniel S Johnson +2 more
doaj +1 more source
The Molecular and Cellular Biophysics of Probiotic Bacteria [PDF]
Biophysical Journal, 2015 Elie Metchnikoff proposed the use of probiotics a century ago. Probiotics regulate the integrity and functionality of gut microbiota. Currently, the scientific attention is more focused on the strain-specific features of probiotics and their use against pathogens or for the treatment of diseases and imbalances of the intestinal microbiota.
openaire +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Plasma Membrane Epichaperome–Lipid Interface: Regulating Dynamics and Trafficking [PDF]
The plasma membrane (PM) of eukaryotic cells plays a key role in the response to stress, acting as the first line of defense against environmental changes and protecting cells against intracellular perturbations.
Ruslana Likhomanova +8 more
core +1 more source
Biophysical Regulation of Cellular Function in Bone
, 2022 Osteoporosis is the most prevalent bone disease and represents a major public health burden. Resulting from a reduction in bone quality and quantity, it can lead to fragility fractures with significant associated morbidity and mortality. Mechanical loading is a potent, albeit incompletely understood, anabolic stimulus that could lead to novel therapies
openaire +2 more sources
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Roughness of Transmembrane Helices Reduces Lipid Membrane Dynamics
iScience, 2018 Summary: The dynamics of cellular membranes is primarily determined by lipid species forming a bilayer. Proteins are considered mainly as effector molecules of diverse cellular processes.
Marie Olšinová +7 more
doaj +1 more source