Results 21 to 30 of about 1,355,354 (296)
Electrostatics in Computational Biophysics and Its Implications for Disease Effects
, 2022 This review outlines the role of electrostatics in computational molecular biophysics and its implication in altering wild-type characteristics of biological macromolecules, and thus the contribution of electrostatics to disease mechanisms.
Sun, Shengjie +7 more
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Metabolomic profiling of ZrO2 nanoparticles in MC3T3‐E1 cells
IET Nanobiotechnology, 2021 The authors' previous study showed that zirconium oxide nanoparticles (ZrO2 NPs) induce toxic effects in MC3T3‐E1 cells; however, its toxicological mechanism is still unclear.
Mingfu Ye +3 more
doaj +1 more source
Cell Reports, 2016 Release site clearance is an important process during synaptic vesicle (SV) recycling. However, little is known about its molecular mechanism. Here we identify self-assembly of exocytosed Synaptobrevin 2 (Syb2) and Synaptophysin 1 (Syp1) by homo- and ...
Rajit Rajappa +4 more
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iScience, 2022 Summary: Cholesterol is a major regulator of multiple types of ion channels. Although there is increasing information about cholesterol binding sites, the molecular mechanisms through which cholesterol binding alters channel function are virtually ...
Nicolas Barbera +8 more
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In vitro assembly, positioning and contraction of a division ring in minimal cells
Nature Communications, 2022 Constructing a minimal protein machinery for self-division of membrane compartments is a major goal of bottom-up synthetic biology. Here, authors achieved the assembly, placement and onset of contraction of a minimal division ring in lipid vesicles.
Shunshi Kohyama +2 more
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Temperature-sensitive migration dynamics in neutrophil-differentiated HL-60 cells
Scientific Reports, 2022 Cell migration plays an essential role in wound healing and inflammatory processes inside the human body. Peripheral blood neutrophils, a type of polymorphonuclear leukocyte (PMN), are the first cells to be activated during inflammation and subsequently ...
Galina Khachaturyan +9 more
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Single-Molecule Cellular Biophysics [PDF]
Journal of Biomedical Optics, 2013 Recent advances in single molecule science have presented a new branch of science: single molecule cellular biophysics, combining classical cell biology with cutting-edge single molecule biophysics. This textbook explains the essential elements of this new discipline, from the state-of-the-art single molecule techniques to real-world applications in ...
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RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation
Acta Neuropathologica Communications, 2021 The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal muscle contraction.
Qi Yuan +9 more
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Biophysical and biomolecular determination of cellular age in humans [PDF]
Nature Biomedical Engineering, 2017 Ageing research has focused either on assessing organ- and tissue-based changes, such as lung capacity and cardiac function, or on changes at the molecular scale such as gene expression, epigenetic modifications and metabolism. Here, by using a cohort of 32 samples of primary dermal fibroblasts collected from individuals between 2 and 96 years of age ...
Jude M, Phillip +11 more
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Synthetic cell division via membrane-transforming molecular assemblies
BMC Biology, 2019 Reproduction, i.e. the ability to produce new individuals from a parent organism, is a hallmark of living matter. Even the simplest forms of reproduction require cell division: attempts to create a designer cell therefore should include a synthetic cell ...
Simon Kretschmer +3 more
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