Results 31 to 40 of about 1,727 (169)

Myosin motors fragment and compact membrane-bound actin filaments

eLife, 2013
Cell cortex remodeling during cell division is a result of myofilament-driven contractility of the cortical membrane-bound actin meshwork. Little is known about the interaction between individual myofilaments and membrane-bound actin filaments.
Sven K Vogel, Zdenek Petrasek, Fabian Heinemann, Petra Schwille   +3 more
doaj   +1 more source

The speed of FtsZ treadmilling is tightly regulated by membrane binding

Scientific Reports, 2020
As one of the key elements in bacterial cell division, the cytoskeletal protein FtsZ appears to be highly involved in circumferential treadmilling along the inner membrane, yielding circular vortices when transferred to flat membranes.
Daniela A. García-Soriano, Tamara Heermann, Ana Raso, Germán Rivas, Petra Schwille   +4 more
doaj   +1 more source

Reconstitution of contractile actomyosin rings in vesicles

Nature Communications, 2021
Cytoskeletal networks support and direct cell shape and guide intercellular transport, but relatively little is understood about the self-organization of cytoskeletal components on the scale of an entire cell.
Thomas Litschel, Charlotte F. Kelley, Danielle Holz, Maral Adeli Koudehi, Sven K. Vogel, Laura Burbaum, Naoko Mizuno, Dimitrios Vavylonis, Petra Schwille   +8 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Small Physical Cross-Linker Facilitates Hyaluronan Hydrogels

Molecules, 2020
In this study, we demonstrate that small charged molecules (NH4+, GluA+, dHA+) can form physical cross-links between hyaluronan chains, facilitating polymerization reactions between synthetically introduced thiol groups (HA-DTPH).
Saliha Erikci, Patricia Mundinger, Heike Boehm   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Machine learning-aided design and screening of an emergent protein function in synthetic cells

Nature Communications
Recently, utilization of Machine Learning (ML) has led to astonishing progress in computational protein design, bringing into reach the targeted engineering of proteins for industrial and biomedical applications.
Shunshi Kohyama, Béla P. Frohn, Leon Babl, Petra Schwille   +3 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Inducing Lipid Domains in Membranes by Self‐Assembly of DNA Origami

Advanced Materials Interfaces, 2023
Self‐assembly of biological molecules and structures is a fundamental property of life. Whereas most biological functions are based on self‐assembled proteins and protein complexes, the self‐assembly of lipids is important for the spatial organization of
Nishu Kanwa, Svetozar Gavrilovic, Gereon A. Brüggenthies, Yusuf Qutbuddin, Petra Schwille   +4 more
doaj   +1 more source