Results 51 to 60 of about 121,160 (299)
Nature CommunicationsFibrolamellar Hepatocellular Carcinoma (FLC) is a rare liver cancer characterized by a fusion oncokinase of the genes DNAJB1 and PRKACA, the catalytic subunit of protein kinase A (PKA).
David Requena +7 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Bioelectricity in Developmental Patterning and Size Control: Evidence and Genetically Encoded Tools in the Zebrafish Model [PDF]
, 2023 Developmental patterning is essential for regulating cellular events such as axial patterning, segmentation, tissue formation, and organ size determination during embryogenesis.
Martin R. Silic, GuangJun Zhang
core +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
High-resolution NMR studies of antibiotics in cellular membranes [PDF]
, 2018 The alarming rise of antimicrobial resistance requires antibiotics with unexploited mechanisms.Ideal templates could be antibiotics that target the peptidoglycan precursor lipid II,known as the bacterial Achilles heel, at an irreplaceable pyrophosphate ...
Breukink, Eefjan +12 more
core +1 more source
Stability of Intracellular Protein Concentration under Extreme Osmotic Challenge [PDF]
, 2021 Cell volume (CV) regulation is typically studied in short-term experiments to avoid complications resulting from cell growth and division. By combining quantitative phase imaging (by transport-of-intensity equation) with CV measurements (by the exclusion
Michael A. Model, Jordan E. Hollembeak
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FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
The Cellular Potts Model on Disordered Lattices [PDF]
This is the data package for the publication with the above title. The data to reproduce the figures in the manuscript and the Supplementary information is provided in the folder "Data".
Hossein Nemati (Utrecht University)
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Regulation and Functions of ROP GTPases in Plant–Microbe Interactions [PDF]
, 2020 Rho proteins of plants (ROPs) form a specific clade of Rho GTPases, which are involved in either plant immunity or susceptibility to diseases. They are intensively studied in grass host plants, in which ROPs are signaling hubs downstream of both cell ...
Stefan Engelhardt +2 more
core +1 more source
Tuning between Nuclear Organization and Functionality in Health and Disease [PDF]
, 2023 The organization of eukaryotic genome in the nucleus, a double-membraned organelle separated from the cytoplasm, is highly complex and dynamic. The functional architecture of the nucleus is confined by the layers of internal and cytoplasmic elements ...
Kishore Sesham +11 more
core +1 more source