Results 71 to 80 of about 121,160 (299)
Micro- and nanotechnology for cell biophysics [PDF]
, 2015 Procedures and methodologies used in cell biophysics have been improved tremendously with the revolutionary advances witnessed in the micro- and nanotechnology in the last two decades.
Kelemen Lóránd +2 more
core +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The Skin Barrier: A System Driven by Phase Separation [PDF]
The mammalian epidermis forms a critical barrier against environmental insults and water loss. The formation of its outermost layer, the stratum corneum, involves a rapid terminal differentiation process that has traditionally been explained by the ...
Wenhua Xu +5 more
core +1 more source
Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal Septin7 [PDF]
, 2023 Septin7 as a unique member of the GTP binding protein family, is widely expressed in the eukaryotic cells and considered to be essential in the formation of hetero-oligomeric septin complexes.
Szabó, László +19 more
core +1 more source
Small Physical Cross-Linker Facilitates Hyaluronan Hydrogels
Molecules, 2020 In this study, we demonstrate that small charged molecules (NH4+, GluA+, dHA+) can form physical cross-links between hyaluronan chains, facilitating polymerization reactions between synthetically introduced thiol groups (HA-DTPH).
Saliha Erikci +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Sensing the Stiffness: Cellular Mechano-Sensing at the Implant Interface [PDF]
In this perspective, we highlight the relevance of the FA-Hippo signaling pathway and its regulation of the Yes-associated protein (YAP) and the transcriptional coactivator with a PDZ-binding domain (TAZ) as main players in the process of implants ...
Raja Devesh Kumar Misra +7 more
core +1 more source
MULTISCALE MEASUREMENTS OF ELECTRICAL & MECHANICAL CELLULAR DYNAMICS [PDF]
, 2023 This dissertation focuses on the study and measurement of coupled electrical and mechanical responses in mammalian cells, tissues, and organs. Cellular biophysics often studies forces and their impact on biochemical pathways.
Alvarez, Phillip
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Machine learning-aided design and screening of an emergent protein function in synthetic cells
Nature CommunicationsRecently, utilization of Machine Learning (ML) has led to astonishing progress in computational protein design, bringing into reach the targeted engineering of proteins for industrial and biomedical applications.
Shunshi Kohyama +3 more
doaj +1 more source