Synthetic cell division via membrane-transforming molecular assemblies
BMC Biology, 2019 Reproduction, i.e. the ability to produce new individuals from a parent organism, is a hallmark of living matter. Even the simplest forms of reproduction require cell division: attempts to create a designer cell therefore should include a synthetic cell ...
Simon Kretschmer +3 more
doaj +1 more source
Biophysical and biomolecular determination of cellular age in humans [PDF]
Nature Biomedical Engineering, 2017 Ageing research has focused either on assessing organ- and tissue-based changes, such as lung capacity and cardiac function, or on changes at the molecular scale such as gene expression, epigenetic modifications and metabolism. Here, by using a cohort of 32 samples of primary dermal fibroblasts collected from individuals between 2 and 96 years of age ...
Jude M, Phillip +11 more
openaire +2 more sources
Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation [PDF]
, 2022 The static magnetic fields (SMFs) impact on biological systems, induce a variety of biological responses, and have been applied to the clinical treatment of diseases. However, the underlying mechanisms remain largely unclear.
Zhen Zhang +29 more
core +1 more source
Hackathons for biophysics education: simulating the cytoskeleton [PDF]
Hackathons are intensive innovation-oriented events where participants work in teams to solve problems or create projects in as little as 24 or 48 hours. These events are common in startup culture, open source communities and mainstream industry. Here we
Zimmer, Patrick +7 more
core +1 more source
Revealing the Heterogeneity of the Tumor Ecosystem of Cholangiocarcinoma through Single-Cell Transcriptomics [PDF]
, 2023 The prognosis of cholangiocarcinoma remains poor. The heterogeneity of the tumor ecosystem of cholangiocarcinoma plays a critical role in tumorigenesis and therapeutic resistance, thereby affecting the clinical outcome of patients with cholangiocarcinoma.
Xin Wang +3 more
core +1 more source
Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations [PDF]
Cellular memory is the competence of cells to preserve information from past experiences and respond aptly. This memory is maintained and controlled by gene regulatory networks (GRNs).
Debmalya Bhunia +4 more
core +1 more source
Combining Micropipette and Atomic Force Microscopy for Single cell Drug Delivery and Simultaneous Cell Mechanics Measurement [PDF]
, 2022 Objective Cell mechanics plays an important role in cellular physiological and pathological processes and is closely related to the health states of living organisms. Investigating cell mechanics significantly benefits revealing the underlying mechanisms
Feng Ya-Qi, Li Mi, Shi Jia-Lin, Yu Peng
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Precision Medicine: Steps along the Road to Combat Human Cancer [PDF]
, 2020 The diagnosis and treatment of diseases such as cancer is becoming more accurate and specialized with the advent of precision medicine techniques, research and treatments.
Samuel F. Nassar +4 more
core +1 more source