Results 41 to 50 of about 1,355,354 (296)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Automated synthetic cell-based screening for designed proteins with emergent functions
Nature CommunicationsDesigning minimal biological systems with emergent functions such as spatiotemporal self-organization is a central goal of bottom-up synthetic biology.
Kareem Al Nahas +4 more
doaj +1 more source
The speed of FtsZ treadmilling is tightly regulated by membrane binding
Scientific Reports, 2020 As one of the key elements in bacterial cell division, the cytoskeletal protein FtsZ appears to be highly involved in circumferential treadmilling along the inner membrane, yielding circular vortices when transferred to flat membranes.
Daniela A. García-Soriano +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Myosin motors fragment and compact membrane-bound actin filaments
eLife, 2013 Cell cortex remodeling during cell division is a result of myofilament-driven contractility of the cortical membrane-bound actin meshwork. Little is known about the interaction between individual myofilaments and membrane-bound actin filaments.
Sven K Vogel +3 more
doaj +1 more source
, 2022 Nearly half a century has passed since the discovery of cytoplasmic inheritance of human chloramphenicol resistance. The inheritance was then revealed to take place maternally by mitochondrial DNA (mtDNA).
Szabó, Ágnes +11 more
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Reconstitution of contractile actomyosin rings in vesicles
Nature Communications, 2021 Cytoskeletal networks support and direct cell shape and guide intercellular transport, but relatively little is understood about the self-organization of cytoskeletal components on the scale of an entire cell.
Thomas Litschel +8 more
doaj +1 more source
, 2018 The advent of atomic force microscopy (AFM) provides a powerful tool for probing the physical properties of native biological samples with unprecedented spatiotemporal resolution at the micro/nanoscale, significantly complementing traditional biochemical
Li Mi +3 more
core +1 more source