Results 41 to 50 of about 1,916,376 (328)
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. [PDF]
, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Corbett, Kevin D +5 more
core +2 more sources
Biophysics of Notch Signaling.
Annual Review of Biophysics, 2021 Notch signaling is a conserved system of communication between adjacent cells, influencing numerous cell fate decisions in the development of multicellular organisms. Aberrant signaling is also implicated in many human pathologies. At its core, Notch has
D. Sprinzak, S. Blacklow
semanticscholar +1 more source
An unfolded protein-induced conformational switch activates mammalian IRE1. [PDF]
, 2017 The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells.
Acosta-Alvear, Diego +5 more
core +3 more sources
The Effects of Temperature on Cellular Physiology.
Annual Review of Biophysics, 2022 Temperature impacts biological systems across all length and timescales. Cells and the enzymes that comprise them respond to temperature fluctuations on short timescales, and temperature can affect protein folding, the molecular composition of cells, and
Benjamin D. Knapp, K. C. Huang
semanticscholar +1 more source
Synthetic cell division via membrane-transforming molecular assemblies
BMC Biology, 2019 Reproduction, i.e. the ability to produce new individuals from a parent organism, is a hallmark of living matter. Even the simplest forms of reproduction require cell division: attempts to create a designer cell therefore should include a synthetic cell ...
Simon Kretschmer +3 more
doaj +1 more source
Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. [PDF]
, 2019 TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a ...
Han, Tina W +4 more
core +2 more sources
The membrane surface as a platform that organizes cellular and biochemical processes.
Developmental Cell, 2023 Membranes are essential for life. They act as semi-permeable boundaries that define cells and organelles. In addition, their surfaces actively participate in biochemical reaction networks, where they confine proteins, align reaction partners, and ...
T. Leonard, Martin Loose, Sascha Martens
semanticscholar +1 more source
Twirling and Whirling: Viscous Dynamics of Rotating Elastica
, 1999 Motivated by diverse phenomena in cellular biophysics, including bacterial flagellar motion and DNA transcription and replication, we study the overdamped nonlinear dynamics of a rotationally forced filament with twist and bend elasticity.
A. E. H. Love +33 more
core +1 more source
Universal protein fluctuations in populations of microorganisms
, 2012 The copy number of any protein fluctuates among cells in a population; characterizing and understanding these fluctuations is a fundamental problem in biophysics.
Braun, Erez +7 more
core +1 more source
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. [PDF]
, 2020 The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization.
Myasnikov, Alexander +3 more
core +3 more sources