Results 21 to 30 of about 3,445,878 (379)

Nano-immunotherapy for each stage of cancer cellular immunity: which, why, and what?

Theranostics, 2021
Immunotherapy provides a new avenue for combating cancer. Current research in anticancer immunotherapy is primary based on T cell-mediated cellular immunity, which can be divided into seven steps and is named the cancer-immunity cycle.
Shiyi Zuo, Jiaxuan Song, Jingxuan Zhang, Zhonggui He, Bingjun Sun, J. Sun   +5 more
semanticscholar   +1 more source

Potential screening indicators for early diagnosis of NAFLD/MAFLD and liver fibrosis: Triglyceride glucose index–related parameters

Frontiers in Endocrinology, 2022
ImportanceHomeostatic model assessment for insulin resistance (HOMA-IR) and triglyceride glucose (TyG) index–related parameters [TyG index, triglyceride glucose–waist circumference (TyG-WC), triglyceride glucose–waist-to-height ratio (TyG-WHtR), and ...
Yan Xue, Jiahui Xu, Man Li, Yueqiu Gao
doaj   +1 more source

Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a Profound NKT Cell Impairment

mBio, 2021
Wuhan was the very first city hit by SARS-CoV-2. Accordingly, the patients who experienced the longest phase of convalescence following COVID-19 reside here. ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory
Jia Liu, Xuecheng Yang, Hua Wang, Ziwei Li, Huihong Deng, Jing Liu, Shu-e Xiong, Junyi He, Xue-mei Feng, Chun-xia Guo, Weixian Wang, Gennadiy Zelinskyy, M. Trilling, K. Sutter, T. Senff, C. Menne, J. Timm, Yanfang Zhang, F. Dèng, Yin-ping Lu, Jun Wu, Mengji Lu, Dongliang Yang, U. Dittmer, Baoju Wang, Xin Zheng   +25 more
semanticscholar   +1 more source

Analysis of the Dynamic Proteasome Structure by Cross-Linking Mass Spectrometry

Biomolecules, 2021
The 26S proteasome is a macromolecular complex that degrades proteins maintaining cell homeostasis; thus, determining its structure is a priority to understand its function.
Marta L. Mendes, Gunnar Dittmar
doaj   +1 more source

Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

Cancer Discovery, 2022
Therapy-induced senescence renders cancer cells highly immunogenic, making them very efficient in triggering protective CD8-dependent antitumor immune responses.
I. Marín, Olga Boix, Andrea García-Garijo, I. Sirois, Adrià Caballé, E. Zarzuela, Irene Ruano, Camille Stephan-Otto Attolini, Neus Prats, J. López-Domínguez, M. Kovatcheva, E. Garralda, Javier Muñoz, E. Caron, M. Abad, A. Gros, F. Pietrocola, M. Serrano   +17 more
semanticscholar   +1 more source

Characterization of the Bronchoalveolar Lavage Fluid by Single Cell Gene Expression Analysis in Healthy Dogs: A Promising Technique

Frontiers in Immunology, 2020
Single-cell mRNA-sequencing (scRNA-seq) is a technique which enables unbiased, high throughput and high-resolution transcriptomic analysis of the heterogeneity of cells within a population.
Aline Fastrès, Dimitri Pirottin, Laurence Fievez, Thomas Marichal, Christophe J. Desmet, Fabrice Bureau, Cécile Clercx   +6 more
doaj   +1 more source

Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer

Cell Discovery, 2023
CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of immunotherapy against microsatellite stable (MSS) CRC is limited.
Daniel Morales Borràs, Sara Verbandt, Markus Ausserhofer, Gregor Sturm, Jinyeong Lim, Gil Arasa Verge, Isaure Vanmeerbeek, Raquel S. Laureano, Jannes Govaerts, Jenny Sprooten, Yourae Hong, Rebecca Wall, Gert De Hertogh, Xavier Sagaert, Gabriele Bislenghi, André D’Hoore, Albert Wolthuis, Francesca Finotello, Woong-Yang Park, Stefan Naulaerts, Sabine Tejpar, Abhishek D. Garg   +21 more
doaj   +1 more source

Association of systemic cellullar immunity with the development of cataract

Медицинская иммунология, 2022
Among the causes of visual impairment, cataract occupies a significant proportion, which indicates a need for studying the causes of its development.
R. E. Osmanov, O. L. Fabrikantov
doaj   +1 more source

Foxp3+ Regulatory T Cells Inhibit CCl4-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity

Frontiers in Immunology, 2020
Foxp3+ regulatory T (Treg) cells are pivotal in maintaining immunological self-tolerance and tissue homeostasis; however, it remains unclear how tissue Treg cells respond to liver injury and regulate chronic inflammation, which can cause liver fibrosis ...
Yoshinobu Ikeno, Daiya Ohara, Yusuke Takeuchi, Hitomi Watanabe, G. Kondoh, K. Taura, S. Uemoto, K. Hirota   +7 more
semanticscholar   +1 more source

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

Cells, 2020
Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain unresponsive to ICBs due to widespread immuno-resistance.
Jenny Sprooten, Pieter De Wijngaert, Isaure Vanmeerbeek, Shaun Martin, Peter Vangheluwe, Susan Schlenner, Dmitri V. Krysko, Jan B. Parys, Geert Bultynck, Peter Vandenabeele, Abhishek D. Garg   +10 more
doaj   +1 more source