Results 21 to 30 of about 3,724,194 (363)

Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer

Cell Discovery, 2023
CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of immunotherapy against microsatellite stable (MSS) CRC is limited.
Daniel Morales Borràs, Sara Verbandt, Markus Ausserhofer, Gregor Sturm, Jinyeong Lim, Gil Arasa Verge, Isaure Vanmeerbeek, Raquel S. Laureano, Jannes Govaerts, Jenny Sprooten, Yourae Hong, Rebecca Wall, Gert De Hertogh, Xavier Sagaert, Gabriele Bislenghi, André D’Hoore, Albert Wolthuis, Francesca Finotello, Woong-Yang Park, Stefan Naulaerts, Sabine Tejpar, Abhishek D. Garg   +21 more
doaj   +1 more source

Metabolic Inflammation and Cellular Immunity

Cells, 2023
Metabolic and immune cell responses are intimately linked and cross-regulated [...]
Sardar Sindhu, Rasheed Ahmad
doaj   +1 more source

Foxp3+ Regulatory T Cells Inhibit CCl4-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity

Frontiers in Immunology, 2020
Foxp3+ regulatory T (Treg) cells are pivotal in maintaining immunological self-tolerance and tissue homeostasis; however, it remains unclear how tissue Treg cells respond to liver injury and regulate chronic inflammation, which can cause liver fibrosis ...
Yoshinobu Ikeno, Daiya Ohara, Yusuke Takeuchi, Hitomi Watanabe, G. Kondoh, K. Taura, S. Uemoto, K. Hirota   +7 more
semanticscholar   +1 more source

Mosquito cellular immunity at single-cell resolution

Science, 2020
Teasing apart the mosquito immune system Hemocytes are key immune cells of insects, playing a major role in how vector species transmit disease. Raddi et al. collected and sequenced the RNA of more than 8000 individual hemocytes from the disease-carrying
G. Raddi, A. Barletta, M. Efremova, J. Ramírez, R. Cantera, S. Teichmann, C. Barillas-Mury, O. Billker   +7 more
semanticscholar   +1 more source

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

Cells, 2020
Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain unresponsive to ICBs due to widespread immuno-resistance.
Jenny Sprooten, Pieter De Wijngaert, Isaure Vanmeerbeek, Shaun Martin, Peter Vangheluwe, Susan Schlenner, Dmitri V. Krysko, Jan B. Parys, Geert Bultynck, Peter Vandenabeele, Abhishek D. Garg   +10 more
doaj   +1 more source

Varying Cellular Immune Response against SARS-CoV-2 after the Booster Vaccination: A Cohort Study from Fukushima Vaccination Community Survey, Japan

Vaccines, 2023
Booster vaccination reduces the incidence of severe cases and mortality related to COVID-19, with cellular immunity playing an important role. However, little is known about the proportion of the population that has achieved cellular immunity after ...
Yuta Tani, Morihito Takita, Yurie Kobashi, Masatoshi Wakui, Tianchen Zhao, Chika Yamamoto, Hiroaki Saito, Moe Kawashima, Sota Sugiura, Yoshitaka Nishikawa, Fumiya Omata, Yuzo Shimazu, Takeshi Kawamura, Akira Sugiyama, Aya Nakayama, Yudai Kaneko, Tetsuhiko Kodama, Masahiro Kami, Masaharu Tsubokura   +18 more
doaj   +1 more source

Extracellular microRNAs initiate immunostimulation via activating toll-like receptor signaling pathways

ExRNA, 2019
Since the discovery of the stability of extracellular microRNAs (miRNAs) in plasma and other body fluids about a decade ago, an increasing body of literature has addressed the function of extracellular miRNAs as novel regulators of gene expression ...
Hongwei Liang, Koby Kidder, Yuan Liu
doaj   +1 more source

A Conserved Tryptophan in the Envelope Cytoplasmic Tail Regulates HIV-1 Assembly and Spread

Viruses, 2022
The HIV-1 envelope (Env) is an essential determinant of viral infectivity, tropism and spread between T cells. Lentiviral Env contain an unusually long 150 amino acid cytoplasmic tail (EnvCT), but the function of the EnvCT and many conserved domains ...
Xenia Snetkov, Tafhima Haider, Dejan Mesner, Nicholas Groves, Schuyler B. van Engelenburg, Clare Jolly   +5 more
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Lentiviral Hematopoietic Stem Cell Gene Therapy Rescues Clinical Phenotypes in a Murine Model of Pompe Disease

Molecular Therapy: Methods & Clinical Development, 2020
Pompe disease is a lysosomal storage disorder caused by malfunctions of the acid alpha-glucosidase (GAA) enzyme with a consequent toxic accumulation of glycogen in cells.
Giuseppa Piras, Claudia Montiel-Equihua, Yee-Ka Agnes Chan, Slawomir Wantuch, Daniel Stuckey, Derek Burke, Helen Prunty, Rahul Phadke, Darren Chambers, Armando Partida-Gaytan, Diego Leon-Rico, Neelam Panchal, Kathryn Whitmore, Miguel Calero, Sara Benedetti, Giorgia Santilli, Adrian J. Thrasher, H. Bobby Gaspar   +17 more
doaj   +1 more source

Structural insights into the biological functions of the long pentraxin PTX3

Frontiers in Immunology, 2023
Soluble pattern recognition molecules (PRMs) are a heterogenous group of proteins that recognize pathogen- and danger-associated molecular patterns (PAMPs and DAMPs, respectively), and cooperate with cell-borne receptors in the orchestration of innate ...
Anna Margherita Massimino, Filippo Emanuele Colella, Barbara Bottazzi, Antonio Inforzato, Antonio Inforzato   +4 more
doaj   +1 more source