Results 71 to 80 of about 3,445,878 (379)

Modeling tumor disease and sepsis by networks of adaptively coupled phase oscillators [PDF]

arXiv, 2021
In this study, we provide a dynamical systems perspective to the modelling of pathological states induced by tumors or infection. A unified disease model is established using the innate immune system as the reference point. We propose a two-layer network model for carcinogenesis and sepsis based upon the interaction of parenchymal cells and immune ...
arxiv  

Anti-EGFR Targeted Monoclonal Antibody Isotype Influences Antitumor Cellular Immunity in Head and Neck Cancer Patients

Clinical Cancer Research, 2016
Purpose: EGF receptor (EGFR) is highly overexpressed on several cancers and two targeted anti-EGFR antibodies which differ by isotype are FDA-approved for clinical use.
S. Trivedi, Raghvendra M Srivastava, F. Concha-Benavente, S. Ferrone, T. M. Garcia-Bates, Jing Li, R. Ferris   +6 more
semanticscholar   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Gallic acid mitigates high-fat and high-carbohydrate diet-induced steatohepatitis by modulating the IRF6/PPARγ signaling pathway

Frontiers in Pharmacology
Gallic acid (GA), a natural organic phenolic compound, is an abundant plant food bioactive substance present in many medicinal herbs. GA has anti-oxidative, anti-inflammatory and anticancer activities on multiple metabolic disorders.
Jiahao Qiu, Jiahao Qiu, Lihong Fu, Yan Xue, Yan Xue, Yilan Yang, Fengjie Qiao, Wanchun Zhu, Yating Gao, Miao Fang, Yufei Liu, Zhujun Gao, Yunfeng Guan, Yunfeng Guan, Yueqiu Gao, Yueqiu Gao, Yueqiu Gao, Xin Zhang, Zhi Shang, Zhi Shang, Zhi Shang   +20 more
doaj   +1 more source

Integration of Cellular and Humoral Immune Responses as an Immunomonitoring Tool for SARS-CoV-2 Vaccination in Healthy and Fragile Subjects

Viruses, 2023
Cellular and humoral immunity are both required for SARS-CoV-2 infection recovery and vaccine efficacy. The factors affecting mRNA vaccination-induced immune responses, in healthy and fragile subjects, are still under investigation.
Giulia Brisotto, Marcella Montico, Matteo Turetta, Stefania Zanussi, Maria Rita Cozzi, Roberto Vettori, Romina Boschian Boschin, Lorenzo Vinante, Fabio Matrone, Alberto Revelant, Elisa Palazzari, Roberto Innocente, Giuseppe Fanetti, Lorenzo Gerratana, Mattia Garutti, Camilla Lisanti, Silvia Bolzonello, Milena Sabrina Nicoloso, Agostino Steffan, Elena Muraro   +19 more
doaj   +1 more source

Critical parameters in dynamic network modeling of sepsis [PDF]

arXiv, 2022
In this work, we propose a dynamical systems perspective on the modeling of sepsis and its organ-damaging consequences. We develop a functional two-layer network model for sepsis based upon the interaction of parenchymal cells and immune cells via cytokines, and the coevolutionary dynamics of parenchymal, immune cells, and cytokines.
arxiv  

Epigenetic Alterations in Cellular Immunity: New Insights into Autoimmune Diseases

Cellular Physiology and Biochemistry, 2017
Epigenetic modification is an additional regulator in immune responses as the genome-wide profiling somehow fails to explain the sophisticated mechanisms in autoimmune diseases.
Zijun Wang, Zhihui Wang, Q. Lu
semanticscholar   +1 more source

Candida albicans colonization and dissemination from the murine gastrointestinal tract : the influence of morphology and Th17 immunity [PDF]

, 2014
This article is protected by copyright. All rights reserved. This work was supported by the Wellcome Trust (086558, 080088, 102705), a Wellcome Trust Strategic Award (097377) and a studentship from the University of Aberdeen. D.K.
Brown, Alistair J P, Brown, Gordon D, Chen, Kong, Drummond, Rebecca A, Gow, Neil A R, Kadosh, David, Kolls, Jay K, MacCallum, Donna M, Murray, Graeme I, Vautier, Simon   +9 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Investigations of cellular immunity in juvenile idiopathic arthritis

Central European Journal of Immunology, 2019
The following was emphasised in an informative, educational issued on the American College of Rheumatology website in April 2017: “About one child in every 1000 develops some type of chronic arthritis.
Lucia Maria Sur, Genel Sur, Gabriel Samasca, Iulia Lupan   +3 more
doaj   +1 more source