Results 71 to 80 of about 870,585 (309)

Measuring Cellular Immunity to Influenza: Methods of Detection, Applications and Challenges

Vaccines, 2015
Influenza A virus is a respiratory pathogen which causes both seasonal epidemics and occasional pandemics; infection continues to be a significant cause of mortality worldwide.
Lynda Coughlan, Teresa Lambe
doaj   +1 more source

On the evolution of decoys in plant immune systems

, 2010
The Guard-Guardee model for plant immunity describes how resistance proteins (guards) in host cells monitor host target proteins (guardees) that are manipulated by pathogen effector proteins.
A Ashkenazi, D Liberto Di, D Shear, H LeBlanc, I Ispolatov, Iaroslav Ispolatov, J Jones, K Bomblies, M Todesco, Michael Doebeli, R Hoorn van der, R Pitti, S Maslov   +12 more
core   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Immunology of oral candidiasis

Journal of Pharmacy and Bioallied Sciences, 2014
A successful pathogen is one that is able to effectively survive and evade detection by the host immune defense. Oral candidiasis has adopted strategies, which evade host defense and eventually cause disease in at-risk patients.
Janardhanam Dineshshankar, Muniapillai Sivakumar, M Karthikeyan, P Udayakumar, K T Shanmugam, G Kesavan   +5 more
doaj   +1 more source

Beneficial autoimmunity at body surfaces – immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer [PDF]

, 2014
Epithelial cells line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental ...
Agrawal, Aguado, Al-Shami, Allakhverdi, Angkasekwinai, Arwert, Balkwill, Bas, Björkström, Blais, Boyden, Briot, Bryson, Burnet, Burnet, Cella, Cerwenka, Champsaur, Chan, Chao, Chavanas, Chen, Chen, Cheroutre, Conticello, Coussens, Culig, Dalton, Dearman, Deleuran, Demehri, DePinho, Devey, Di Piazza, Dighe, Dunham, Dunn, Dvorak, Ehrlich, Eisenbarth, Ellyard, Engkilde, Eyerich, Farhadi, Felices, Fort, Fritz, Fujisawa, Fukuyama, Furmanski, Fux, Gause, Gebhardt, Giangreco, Girardi, Girardi, Girardi, Golumbek, Gregory, Groh, Gutierrez, Hallett, Hammad, Hams, Harris, Hayday, Heneghan, Hock, Hueber, Humphreys, Imai, Indra, Jackson, Jameson, Jameson, Jensen-Jarolim, Jerde, Jiang, Jiang, Josephs, Jotwani, Jovanovic, Jovanovic, Jung, Kaplan, Karagiannis, Kim, Komai-Koma, Kool, Kool, Kouzaki, Kuroda, Lebel-Binay, Lee, Lindelof, Lodoen, Ma, Magalhaes, Magalhaes, Marichal, Marichal, Matsuda, Matzinger, McCoy, McWhorter, Meehan, Metz, Mishra, Moghaddam, Monticelli, Nestle, Nigro, Obiri, Oh, Okumura, Olver, Ortiz-Urda, Owyang, Palm, Palm, Park, Pastorelli, Pearce, Pedroza-Gonzalez, Pericle, Profet, Qi, Ramsbottom, Raulet, Reali, Renard, Rittmeyer, Rodolfo, Rosenberg, Rölle, Saenz, Sagiv, Salgame, Salimi, Schmidt, Schmitz, Schneider, Schonthaler, Senovilla, Shankaran, Sharp, Sherman, Shi, Shibuya, Simson, Skinnider, Smyth, Soriani, South, Strid, Strid, Strid, Suárez-Alvarez, Swamy, Takahashi, Takai, Tan, Tang, Thomas, Traidl-Hoffmann, Turchinovich, Ullrich, Van Belle, Van Hemelrijck, Vantourout, Verdino, Vernersson, Vesely, Villarreal, Walley, Walter, Wang, Wen, Wen, Wilson, Witherden, Witherden, Wood, Yanaba, Yin, Yoo, Zaiss, Zaph, Zaph, Ziegler, Zitvogel   +190 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Immunomodulatory effects of silymarin after subacute exposure to mice: A tiered approach immunotoxicity screening

Journal of Pharmacopuncture, 2018
Silymarin is a flavonoid complex extracted from the Silybum marianum plant with a wide range of pharmacological and biochemical effects. In the present study, the immunomodulatory effects of silymarin were investigated in BALB/c mice.
Gholamreza Karimi, Samed Hassanzadeh-Josan, Bahram Memar, Seyed-Alireza Esmaeili, Bamdad Riahi-Zanjani   +4 more
doaj   +1 more source

Evaluation of Histologically and Histochemically Proven Cases of Vitiligo and its Correlation with CD4+ and CD8+ Lymphocyte Counts using Flow Cytometry [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Vitiligo is an acquired cutaneous disorder characterized by progressive and selective destruction of melanocytes from the epidermis. Autoimmunity is strongly implicated in its pathogenesis.
Moninder Kaur, Permeet Kaur Bagga, Tejinder Kaur, Amarjit Singh   +3 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

FEATURES OF CELLULAR IMMUNITY IN CHILDREN WITH CHRONIC HERPES VIRUS INFECTION DEPENDING ON THE AGE AND DEGREE OF EXPOSURE TO THE DIFFERENT TYPES VIRUSES [PDF]

Annals of Mechnikov's Institute, 2013
The basic parameters of cellular immunity and leukocyte composition of peripheral blood of children suffering HGVI caused by herpes viruses of I-VI types, age groups 3-5, 6-11, 12-14 years, corresponding to different degrees of maturity of immune system,
Volyanskiy A.Yu., Romanova E. A., Igumnova N. I., Sidorenko T. A., Yuchimenko V. I., Konareva K. S.   +5 more
doaj