Results 101 to 110 of about 224,348 (348)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis [PDF]

, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Aigner, S., Anselmo, A., Brumbaugh, J., Charlton, J., Clement, K., Clowers, K., de Kort, M., Di Stefano, B., Gerli, M., Gu, H., Gygi, S., Haggerty, C., Hochedlinger, K., Huebner, A., Ji, F., Lipchina, I., Luo, E., Meissner, A., Pulice, J., Rabano Jiménez, I., Sadreyev, R., Yeo, G.   +21 more
core   +3 more sources

Editorial: Hallmark of cancer: Reprogramming of cellular metabolism [PDF]

, 2023
Baljinder Kaur, Yahya Sohrabi, Abhinav Achreja, Michael P. Lisanti, Ubaldo Emilio Martinez-Outschoorn   +4 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Pluripotency, differentiation, and reprogramming: A gene expression dynamics model with epigenetic feedback regulation

, 2015
Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmental biology. In particular, an understanding of these processes is essential
Furusawa, Chikara, Kaneko, Kunihiko, Miyamoto, Tadashi   +2 more
core   +3 more sources

Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming [PDF]

, 2013
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes ...
A Calender, A Chen, A Chen, A Le Roux, A Mor, A Rada-Iglesias, A Saha, A Sjoblom, A Smith, Aaron Arvey, Aditi Kanhere, AJ Sinclair, B Akhtar-Zaidi, B Kempkes, B Tomkinson, B Tomkinson, B Zhao, B Zhao, B Zhao, B Zhao, Bettina Kempkes, C Kaiser, C Kintner, C Subramanian, C. David Wood, CD Gregory, CF Eisenbeis, D Marshall, D Portal, D Wang, DY Wu, DY Wu, E Anderton, E Johannsen, EM Fuentes-Panana, EO Long, ES Robertson, F Lu, F Nitsche, F Wang, F Wang, F Wang, G Chinnadurai, G Laux, GL Kelly, H Ben-Bassat, Helen M. Webb, I Tempera, J O'Nions, JC Knutson, JI Cohen, JI Cohen, JI Cohen, JM Boyd, JS Knight, K Paschos, K Paschos, KG Krauer, L Skalska, L Skalska, L Waltzer, L Waltzer, L Wang, LC Spender, LC Spender, M Bain, M Bulger, M Cordier, M Hickabottom, M Wade, M Woisetschlaeger, MA Epstein, Marie L. Harth-Hertle, MB Gerstein, Michael J. McClellan, Michelle J. West, MJ Maunders, MJ McClellan, MJ West, ML Hertle, MM Pomerantz, MP Creyghton, N Ahmadiyeh, N Naumova, ND Heintzman, Opeoluwa Ojeniyi, P Nurse, PA Nikitin, Paul M. Lieberman, R Touitou, RD Palermo, RE White, RE White, Richard D. Palermo, Richard G. Jenner, S Banerjee, S Harada, S Maier, S Maruo, S Maruo, S Maruo, S Paliwal, S Tuupanen, SA Radkov, SJ Bark-Jones, SN Schlick, SR Grossman, T Choudhuri, T Henkel, Tim J. Cooper, U Schaeper, U Zimber-Strobl, VS Chopra, W Lucchesi, X Tong, X Tong, X Tong, Y Zhang   +117 more
core   +3 more sources

EfficientNet-B0 outperforms other CNNs in image-based five-class embryo grading: a comparative analysis

Journal of Animal Reproduction and Biotechnology
Background: Evaluating embryo quality is crucial for the success of in vitro fertilization procedures. Traditional methods, such as the Gardner grading system, rely on subjective human assessment of morphological features, leading to potential ...
Vincent Jaehyun Shim, Hosup Shim, Sangho Roh   +2 more
doaj   +1 more source

Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a PITX2 p.M200V mutation

Stem Cell Research, 2017
Atrial fibrillation (AF) is the most common sustained arrhythmia associated with several cardiac risk factors, but increasing evidences indicated a genetic component.
Cristina Mora, Marialaura Serzanti, Alessio Giacomelli, Silvia Beltramone, Eleonora Marchina, Valeria Bertini, Giovanna Piovani, Lena Refsgaard, Morten Salling Olesen, Venusia Cortellini, Patrizia Dell'Era   +10 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Viral hijacking of cellular metabolism. [PDF]

, 2019
This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate.
Ch'ng, James, Christofk, Heather R, Thaker, Shivani K   +2 more
core