Results 121 to 130 of about 123,953 (269)
Stem Cell Research, 2022 Amyotrophic Lateral Sclerosis (ALS) is a fatal disease affecting both upper and lower motoneurons. The transactive response DNA binding protein (TARDBP) gene, encoding for TDP-43, is one of the most commonly mutated gene associated with familial cases of
Angela D'Anzi +13 more
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Advanced Functional Materials, EarlyView.A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song +8 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner +5 more
wiley +1 more source
An Algorithmic Information Calculus for Causal Discovery and Reprogramming Systems [PDF]
arXiv, 2017 We demonstrate that the algorithmic information content of a system is deeply connected to its potential dynamics, thus affording an avenue for moving systems in the information-theoretic space and controlling them in the phase space. To this end we performed experiments and validated the results on (1) a very large set of small graphs, (2) a number of
arxiv
Advanced Healthcare Materials, EarlyView.This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth +10 more
wiley +1 more source
Reprogrammable Mechanical Metamaterials via Passive and Active Magnetic Interactions
Advanced Materials, EarlyView.The combination of flexible matrices with embedded hard‐magnetic nodes enables metastructures with reprogrammable mechanical properties, even in the absence of external magnetic fields. The evolving interaction between nodes during structural deformation allows mechanical tunability under quasi‐static and dynamic loading, and bistable transitions. This
Carlos Perez‐Garcia +7 more
wiley +1 more source
Stem Cell Research, 2018 Smith-Magenis syndrome (SMS) is a complex genetic disorder characterized by developmental delay, behavioural problems and circadian rhythm dysregulation.
Filomena Altieri +12 more
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A Bio‐Inspired Perspective on Materials Sustainability
Advanced Materials, EarlyView.This perspective discusses natural materials as inspiration for sustainable engineering designs and the processing of materials. First, circularity, longevity, parsimony, and activity are presented as essential material paradigms. The perspective then uses many examples of natural and technical materials to introduce principles such as oligo ...
Wolfgang Wagermaier +2 more
wiley +1 more source
Stem Cell Research, 2019 Dentato-Rubral-pallidoluysian atrophy (DRPLA) is a rare autosomal, dominant, progressive neurodegenerative disease that causes involuntary movements, mental and emotional problems.
Eris Bidollari +15 more
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Cellular reprogramming to model and study epigenetic alterations in cancer
Stem Cell Research, 2020 Although genetic mutations are required for cancer development, reversible non-genetic alterations also play a pivotal role in cancer progression. Failure of well-orchestrated gene regulation by chromatin states and master transcription factors can be ...
Jungsun Kim
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