Results 131 to 140 of about 229,443 (256)

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity

Advanced Materials, EarlyView.
This work introduces an injectable mesoporous silica rod scaffold that confines lentiviral vectors to the injection site, enabling localized dendritic cell recruitment and transduction. The platform sustains antigen expression, promotes robust T‐cell activation, and enhances antitumor immunity.
Thanh Loc Nguyen, Yeon‐ju Kim, Jihye Im, Dong Kwang Min, Hyunsu Shin, Thuy An Trinh, Ngoc Man Phan, Min‐jeong Son, Ji‐yeon Shim, Ye‐lim Lee, Yujeong Ha, Kwang‐il Lim, Jaeyun Kim   +12 more
wiley   +1 more source

Photo‐Rewritable Ambipolar Organic Electrochemical Synapses with Bidirectional Optical Plasticity for Adaptive Vision in Aqueous Environments

Advanced Materials, EarlyView.
Photo‐rewritable ambipolar organic synapses operating in aqueous environments at low voltage (≤0.4 V) demonstrate bidirectional optical plasticity through photon‐modulated electrochemical doping. The bulk heterojunction device enables both excitatory and inhibitory responses with extended retention time (>130 min).
Xiaoqian Su, Xihu Wu, He Wang, Wenzhe Lu, Bing Xue, Jinli Tang, Zhangshanhao Li, Kejing Ren, Qiang He, Junyu Li, Lan Yin, Yuxin Liu, Shiming Zhang, Ting Lei, Changsheng Wu   +14 more
wiley   +1 more source

Rewriting Polymer Fate via Chemomechanical Coupling

Advanced Materials, EarlyView.
This work introduces a life‐like “living” polymer platform that can grow, degrow, and reprogram its properties after fabrication. By integrating mass transport, reversible polymerization, and controlled catalysis, the material achieves on‐demand changes in size, shape, and mechanical properties.
Jiahe Huang, Haohui Zhang, Jiehao Chen, Xuelin Sui, Febby Krisnadi, Dongjing He, Huajian Ji, Will R. Gutekunst, Michael D. Dickey, Yuhang Hu   +9 more
wiley   +1 more source

The role of pioneer transcription factors in the induction of direct cellular reprogramming. [PDF]

Regen Ther, 2023
Horisawa K, Suzuki A.
europepmc   +1 more source

Machine Learning–Assisted Bio‐Interfacial Engineering Resolves Structural–Functional Conflicts in Nanocomposites

Advanced Materials, EarlyView.
A machine learning‐guided bio‐interfacial design strategy resolves the long‐standing strength–toughness–functionality trade‐off in nanocomposites. By efficiently mapping high‐performance regions in the composition–processing space, the approach delivers hierarchically entangled, nanosheet‐pinned architectures that combine mechanical robustness ...
Hao Wang, Xianfeng Chen, Peiyao Yan, Siqi Liu, Biaobiao Yan, Junhua Kong, Siew Lang Teo, Kai Jin, Jie Zhang, Ping Koy Lam, Chaobin He   +10 more
wiley   +1 more source

Navigating the landscape of direct cellular reprogramming with DiReG. [PDF]

NPJ Syst Biol Appl
Lauber M, List M.
europepmc   +1 more source