Results 131 to 140 of about 123,953 (269)

The role of pioneer transcription factors in the induction of direct cellular reprogramming. [PDF]

Regen Ther, 2023
Horisawa K, Suzuki A.
europepmc   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions. [PDF]

BMC Biol, 2023
Wang M, He B, Hao Y, Srinivasan D, Shrinet J, Fraser P.   +5 more
europepmc   +1 more source

Challenges and Opportunities of Upconversion Nanoparticles for Emerging NIR Optoelectronic Devices

Advanced Materials, EarlyView.
The special photo‐responsiveness of upconversion nanoparticles has opened up a new path for the advancement of near‐infrared (NIR)‐responsive optoelectronics. However, challenges such as low energy‐conversion efficiency and high nonradiative losses still persist.
Sunyingyue Geng, Hangfei Li, Ziyu Lv, Yongbiao Zhai, Bobo Tian, Ying Luo, Ye Zhou, Su‐Ting Han   +7 more
wiley   +1 more source

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging. [PDF]

Front Aging, 2023
Paine PT, Rechsteiner C, Morandini F, Desdín-Micó G, Mrabti C, Parras A, Haghani A, Brooke R, Horvath S, Seluanov A, Gorbunova V, Ocampo A.   +11 more
europepmc   +1 more source

Carbon Dot‐Linked Hydrogel for TAMs Transform: Spatiotemporal Manipulation to Reshape Tumor Microenvironment

Advanced Materials, EarlyView.
The CDs crosslinked egg white hydrogel loaded with lipopolysaccharide (LPS) and CA170 (TTF‐L‐C) can realize spatiotemporal tumor‐associated macrophages (TAMs) transformation from multi‐level dimensions, including spatial recruitment, cell phenotype reprogramming, and immune checkpoint molecule blockade.
Lingyun Li, Jun Wu, Xue Wu, Zhenjian Li, Xianming Zhang, Zekun Yan, Yingqi Liang, Caishi Huang, Songnan Qu   +8 more
wiley   +1 more source

Mapping, modeling, and reprogramming cell-fate decision making systems [PDF]

arXiv
Many cellular processes involve information processing and decision making. We can probe these processes at increasing molecular detail. The analysis of heterogeneous data remains a challenge that requires new ways of thinking about cells in quantitative, predictive, and mechanistic ways.
arxiv  

3D Printed Magnetic Origami Scaffolds for Guided Tissue Assembly

Advanced Materials Interfaces, EarlyView.
3D‐printed magnetic origami scaffolds enhance 3D coculture by directing cell proliferation pre‐folding, restricting expansion for controlled growth within the channel, and spatially and temporally promoting 3D multicellular dissemination post‐folding.
Brandon Daul, Ryan Martin, Phillip Glass, Reza Moonesi Rad, Richard Inho Joh, Fanben Meng, Daeha Joung   +6 more
wiley   +1 more source

Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing-Fantasy or reality? [PDF]

Chronic Dis Transl Med, 2023
Du J, Liu X, Wong CWY, Wong KKY, Yuan Z.
europepmc   +1 more source

Bioelectrical Interfaces Beyond Cellular Excitability: Cancer, Aging, and Gene Expression Reprogramming [PDF]

arXiv
Bioelectrical interfaces represent a significant evolution in the intersection of nanotechnology and biophysics, offering new strategies for probing and influencing cellular processes. These systems capitalize on the subtle but powerful electric fields within living matter, potentially enabling applications beyond cellular excitability, ranging from ...
arxiv