Results 221 to 230 of about 224,348 (348)

Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration. [PDF]

Cell Rep, 2023
Salinas-Saavedra M, Febrimarsa, Krasovec G, Horkan HR, Baxevanis AD, Frank U.   +5 more
europepmc   +1 more source

Sea urchin immune cells and associated microbiota co-exposed to iron oxide nanoparticles activate cellular and molecular reprogramming that promotes physiological adaptation

Andi Alijagić, Roberta Russo, Viviana Scuderi, Martina Ussia, Silvia Scalese, Simona Taverna, Magnus Engwall, Annalisa Pinsino   +7 more
openalex   +1 more source

Panobinostat Effectively Increases Histone Acetylation and Alters Chromatin Accessibility Landscape in Canine Embryonic Fibroblasts but Does Not Enhance Cellular Reprogramming

, 2021
Maryam Moshref, María Questa, Veronica Lopez-Cervantes, Thomas Sears, Rachel L. Greathouse, Charles K. Crawford, Amir Kol   +6 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Cyclic Stretch Promotes Cellular Reprogramming Process through Cytoskeletal-Nuclear Mechano-Coupling and Epigenetic Modification. [PDF]

Adv Sci (Weinh), 2023
Park SM, Lee JH, Ahn KS, Shim HW, Yoon JY, Hyun J, Lee JH, Jang S, Yoo KH, Jang YK, Kim TJ, Kim HK, Lee MR, Jang JH, Shim H, Kim HW.   +15 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature. [PDF]

Sci Rep, 2023
Horisawa K, Miura S, Araki H, Miura F, Ito T, Suzuki A.   +5 more
europepmc   +1 more source

Systemic evaluation of cellular reprogramming processes exploiting a novel R-tool:eegc [PDF]

, 2017
Xiaoyuan Zhou, Guofeng Meng, Christine Nardini, Hongkang Mei   +3 more
openalex   +1 more source

Cellular Heterogeneity and Molecular Reprogramming of the Host Response during Influenza Acute Lung Injury

, 2022
Kai Guo, Dan Justin Kalenda Yombo, Taylor Schmit, Zhihan Wang, Zahrasadat Navaeiseddighi, Venkatachelem Sathish, Ramkumar Mathur, Min Wu, Bony De Kumar, Junguk Hur, Nadeem Khan   +10 more
openalex   +2 more sources

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source