Results 161 to 170 of about 234,206 (306)

Reviewer #2 (Public review): Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

Changli Zhang, Martha Elena Diaz-Hernandez, Takanori Fukunaga, Shenoy Sreekala, Sangwook Tim Yoon, Lisbet Haglund, Hicham Drissi   +6 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

PRKN-Mediated Ubiquitin-Proteasome Degradation of METTL3 Promotes Cellular Senescence. [PDF]

Aging Cell
Chen L, Zhang C, Ge Y, Zhou H, Yang S, Wei W, Zhou Q, Xiao K, Huang G, Li X, Wang J, Zheng J, Gu R, Ju Z, Wu S.   +14 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cellular Senescence

Reactome - a curated knowledgebase of biological pathways, 2013
openaire   +1 more source

Author Correction: RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Communications Biology
Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, Koutaro Yokote, Mizuho Nakayama, Masanobu Oshima, Koji Nagao, Chikashi Obuse, Satoshi Nagayama, Keiyo Takubo, Akira Nakanishi, Masato T. Kanemaki, Eiji Hara, Akiko Takahashi   +20 more
doaj   +1 more source

The impact of cellular senescence on aging skeletal muscle. [PDF]

Front Cell Dev Biol
Kamal M, Bevington R, Johnson A, Parise G.   +3 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Cellular senescence in age-related cardiovascular disease: past and future. [PDF]

Front Aging
Wu X, Zhou Q, Huang Y, Jiang W, Zhou J, Qian K, Pan Y, Wu Z, Zhang J, Aimaiti M, Zhou Q, Lv F, Lin Y, Li S, Chen S.   +14 more
europepmc   +1 more source

Mir‐23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression [PDF]

, 2015
Zhenhua Luo, Xuyang Feng, Haoli Wang, Weiyi Xu, Yong Zhao, Wenbin Ma, Songshan Jiang, Dan Liu, Junjiu Huang, Zhou Songyang   +9 more
openalex   +1 more source